“It is suggested that the reason for the slight beneficial effect of pyrithioxine on the withdrawal symptoms when taken regularly in combination with ethanol is the slight protection afforded against intoxication.”
“The results indicate that pyrithioxine may affect the symptoms of ethanol withdrawal in different ways, the effect depending on both dose level and time of administration.”
“Therapeutic …) of pyrithioxine (pyritinolum NFN, rINN) (bis-3-hydroxy-4-…)-disulphide dihydrochloride monohydrate) given with the ethanol for 20 days made the rats with withdrawal symptoms significantly more responsive to pain and slightly … sound-induced withdrawal convulsions, but this pretreatment did not markedly prevent the deviations in electrolyte concentrations.”