Possible Interaction: Ethanol and Pulmonary Surfactants

“In alveolar type II cells, chronic ingestion of ethanol altered cellular functions such as decreased surfactant processing, decreased barrier integrity, and increased sensitivity to cytotoxin-induced apoptosis in vitro and in vivo.”

“Recently, we established that chronic ethanol consumption also perturbs surfactant lipid homeostasis in the lung and that elevated concentrations of free fatty acids contribute to blocking essential AM functions, such as agonist-induced cytokine expression.”

“Treatment with an alcohol solvent transferred inhibitory activity to the wash, and mass spectrometry revealed surfactin , a cyclic lipopeptide antibiotic, as the inhibitory compound.”

“At 134 DGA, surfactant phospholipid concentration in amniotic fluid was significantly reduced (P < 0.05) by ethanol exposure, and the composition was altered.”

“Therefore, we hypothesized that ethanol ingestion, via glutathione depletion, could alter surfactant phospholipid distribution between LA and SA forms and thereby exacerbate sepsis-mediated lung dysfunction in vivo.”

“In acute poisoning this suppression is associated with direct injury of surfactant with ethanol and inactivation of surfactant with serum proteins, which appear in the alveolar space because of the edema of air-haematic barrier.”

“In the results of complex investigation of the lungs of 26 white rats, it was established, that there is the suppression of surface active properties of surfactant under influence of ethanol.”

“The results show that the combination of surfactant (lauryl glucoside) and co-surfactant ( ethanol ) can increase SRB activity to about 2.3-fold.”

“After diluting the surfactant solution with ethanol , the lower viscosity leads to an improved penetration inside the mesopores.”

“Furthermore, the surfactant addition obviously increased ethanol yield in SSF process of SECS.”

“The effect of adding an alcohol to surfactant systems depends much on the alcohol chain length.”