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Last Updated: 3 months ago

Possible Interaction: Ethanol and Propylthiouracil

supplement:

Ethanol

Research Papers that Mention the Interaction

This preferential inhibitory effect of PTU was observed either when PTU treatment was started after 20 days of ethanol consumption, or when ethanol and PTU administration were started at the same time.
Biochemical pharmacology  •  1980  |  View Paper
We have previously shown that propylthiouracil PTU ) administration reduces liver oxygen consumption and protects animals fed alcohol chronically against hypoxic liver damage.
Drug and alcohol dependence  •  1979  |  View Paper
Those who tasted PROP as most bitter or had highest numbers of fungiform papilla reported greatest oral burn from an alcohol probe ; those who tasted least PROP bitterness consumed alcoholic beverages most frequently.
Physiology & Behavior  •  2004  |  View Paper
Recently it was observed that the hypothyroid state induced by propylthiouracil treatment reduced the elimination rate of ethanol.
Experimental and molecular pathology  •  2001  |  View Paper
It has been postulated that the beneficial effects of the antithyroid drug propylthiouracil in the treatment of alcoholic liver disease depend primarily on the action of propylthiouracil in suppressing the increase in hepatic oxygen consumption induced by ethanol.
Treatment with propylthiouracil for 5 days resulted in complete suppression of the increase in liver oxygen consumption induced by long‐term ethanol administration.
Hepatology  •  1993  |  View Paper
Ethanol mediated iodide uptake and iodine organification were inhibited by potassium perchlorate and propylthiouracil respectively.
Endocrinology  •  1993  |  View Paper
Treatment with the antithyroid drug 6-n-propyl-2-thiouracil PTU ) during the last 9 days (40 mg/kg/day) of the chronic administration of ethanol reduced hepatic oxygen consumption, resulting in a net diminution of the metabolic tolerance to ethanol, despite a further elevation in ADH activity.
Biochemical pharmacology  •  1985  |  View Paper
However, the portion of ethanol in the total caloric intake of the rats was significantly increased by propylthiouracil treatment and significantly decreased by triiodothyronine treatment while the total caloric intake did not correlate positively with the voluntary alcohol consumption of these animals.
Acta pharmacologica et toxicologica  •  1971  |  View Paper