Possible Interaction: Ethanol and Propylthiouracil

“This preferential inhibitory effect of PTU was observed either when PTU treatment was started after 20 days of ethanol consumption, or when ethanol and PTU administration were started at the same time.”

“We have previously shown that propylthiouracil PTU ) administration reduces liver oxygen consumption and protects animals fed alcohol chronically against hypoxic liver damage.”

“Those who tasted PROP as most bitter or had highest numbers of fungiform papilla reported greatest oral burn from an alcohol probe ; those who tasted least PROP bitterness consumed alcoholic beverages most frequently.”

“Recently it was observed that the hypothyroid state induced by propylthiouracil treatment reduced the elimination rate of ethanol.”

“It has been postulated that the beneficial effects of the antithyroid drug propylthiouracil in the treatment of alcoholic liver disease depend primarily on the action of propylthiouracil in suppressing the increase in hepatic oxygen consumption induced by ethanol.”

“Treatment with propylthiouracil for 5 days resulted in complete suppression of the increase in liver oxygen consumption induced by long‐term ethanol administration.”

“ Ethanol mediated iodide uptake and iodine organification were inhibited by potassium perchlorate and propylthiouracil respectively.”

“Treatment with the antithyroid drug 6-n-propyl-2-thiouracil PTU ) during the last 9 days (40 mg/kg/day) of the chronic administration of ethanol reduced hepatic oxygen consumption, resulting in a net diminution of the metabolic tolerance to ethanol, despite a further elevation in ADH activity.”

“However, the portion of ethanol in the total caloric intake of the rats was significantly increased by propylthiouracil treatment and significantly decreased by triiodothyronine treatment while the total caloric intake did not correlate positively with the voluntary alcohol consumption of these animals.”