Possible Interaction: Ethanol and Propranolol

“The amount of daily consumption of alcohol also predicted to some extent the effects of propranolol.”

“Treatment with propranolol significantly decreased BP and HR for 24 h. Propranolol and alcohol showed an additive depressor effect on night-time BP, and the alcohol-induced hypotension was similar before and after propranolol treatment.”

“ Propranolol significantly (p less than 0.05) antagonized the decrement in psychomotor performance induced by ethanol on the PM.”

“ Ethanol inhibits the hepatic oxidative metabolism of propranolol in vitro; however, any effect on heart rate of higher concentrations of propranolol induced by ethanol in humans is off-set by the cardio-acceleratory effect of ethanol.”

“SummaryStudies were conducted to determine the mechanism whereby ethanol alters the hepatic disposition of propranolol.”

“The extent of the propranolol-induced slowing of heart rate was not influenced by ethanol (mean … of 13 bpm at peak propranolol effect vs 9 bpm without ethanol); mean heart rates following propranolol … ethanol were higher at all times (mean of 7.…) (p<0.001) than after propranolol alone.”

“These results suggest that ethanol could substantially increase the oral bioavailability of propranolol in humans.”

“…,ethanol ( $$\bar x$$ =… of dl-propranolol (1.93±0.43 to 1.24±0.22 ml/min/g liver, p<0.05); increased its t1/2 (12.8±… min, p<0.01); and decreased the proportion metabolized (68.7±4.7% to 34.3±10.3%, p<0.01).”

“In the rat, circulating troponin-T release increases in the presence of ethanol , a mechanism ascribed to free radical mediated damage, as it is prevented with the xanthine oxidase inhibitor and beta-blocker, propranolol.”

“BACKGROUND The reconsolidation blocker propranolol abolishes alcohol and drug-seeking behavior in rodents and attenuates conditioned emotional responses to drug-cues in humans in experimental settings.”

“A 31-year-old woman ingested approximately 3.6 g of propranolol along with ethanol.”

“ Ethanol significantly increased the steady-state peak concentration of propranolol while propranolol significantly reduced the total body clearance of ethanol in healthy human volunteers.”

“ Propranolol , an inhibitor of diacylglycerol formation from phosphatidic acid, caused a prolonged transmembrane influx of Ca2+ and partially reversed the inhibitory effect of ethanol on FMLP-induced O2- production.”

“The reduction in the effect of propranolol after alcohol was small and not seen consistently.”

“with these kinetic observations, Sotaniemi and his colleagues'2 found that the effect of propranolol in reducing the blood pressure was diminished after alcohol while the effects of sotalol were enhanced.”