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“Despite the circumstances surrounding the patient’s episode and her suggestive history, in the absence of supportive literature, the reason for the cross-reactivity between alcohol and propofol (as manifested by a common symptom) is unknown.”
“Because alcohol and propofol have a common site of action, we postulated that paradoxical excitement responses during propofol-induced sedation occur more frequently in hazardous and harmful alcohol drinkers than in social or non-drinkers.”
British journal of anaesthesia • 2011 | View Paper
“During ethanol infusion, propofol produced a greater rate-dependent decrease in excitability, manifested by a longer minimum paced CL with 1:1 atrial capture: 145 (11) vs 164 (27) ms in the T- and P-group, respectively (P=0.01).”