Possible Interaction: Ethanol and Proline

“However, if alcohol misuse influences PRO completion, selection bias may result.”

“In vitro ethanol causes a significant increase in the incorporation of proline and hydroxyproline into collagen in biopsy specimens of alcoholic hepatitis or active cirrhosis, but has no effect on collagen synthesis by normal or fatty liver.”

“Biological pathways that were disproportionally altered by alcohol were proline and citrulline biosynthesis/metabolism.”

“We hypothesized that this proline residue could affect the size and orientation of the putative alcohol and anesthetic binding pocket and perhaps explain some of the differences in alcohol and anesthetic effects seen in this family of receptors.”

“ Chronic ethanol treatment produced a decrease in the arteriovenous differences of Asp, Thr, Arg, Met and Phe, and increased those of Ala, Gln, Gly, Pro and Tyr.”

“ Ethanol treatment decreased the arterial levels of Ala, Asp, Gly, Pro , Lys and Met, and increased those of Gln and alpha-amino-butyrate.”

“When metabolic activity of the cultured cells was expressed … in purified mucus glycoprotein, it was found that ethanol at low concentration (0.1 … 9-fold increase in proline and a 5- to 6-fold increase in palmitic acid incorporation … 1.5 M ethanol, the synthetic processes ceased to function.”

“Intracellular glutamine, tyrosine and proline increased in concentration with ethanol , but the increases were too small to explain the observed inhibition of proteolysis.”

“Its accumulation from ethanol was enhanced both by proline and lactate.”

“While uptake of proline was markedly increased by ethanol and acetaldehyde, proline pool sizes were not significantly changed.”

“Since ethanol retards the breakdown of proline , it might be expected that ethanol-induced liver cirrhosis could be produced by the effect of ethanol on the hepatic proline level.”