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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Procainamide
Research Papers that Mention the Interaction
“2 In both studies, ethanol caused a significant reduction of T1/2 and a significant increase in total clearance of procainamide , while the apparent volume of distribution of procainamide, as well as the renal clearance of both procainamide and N-acetylprocainamide were unaffected by ethanol treatment.”
Ethanol-induced increase in procainamide acetylation in man.“As determined … data, both ethanol treatments significantly decreased the distribution clearance (CLd; k12Vdc) and the … from the central compartment to the tissue compartment (k12) of procainamide without affecting the total body clearance of drug (CL) or the apparent … body at steady state (Vdss) and at pseudo-equilibrium (Vd beta).”
Effects of chronic ethanol ingestion on pharmacokinetics of procainamide in rats.“Concomitant oral administration of ethanol and procainamide decreased the peak plasma concentration and decreased the area under the drug level curve.”
“ Ethanol shortened biological half-life of procainamide elimination , increased the value of the rate constant of elimination and procainamide clearance.”
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