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“We propose that many of … prominent adverse effects of chronic prenatal exposure … ethanol on CNS development and function may be prevented or reduced by treatment with peroxisome-proliferated activated receptor (PPAR) … which enhance insulin sensitivity by increasing expression and function of insulin-responsive genes, and reducing cellular oxidative stress.”
Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharamcologie clinique • 2010 | View Paper
“Children who have a history of prenatally exposure to ethanol may show morphological and functional alterations, referred to as fetal alcohol spectrum disorders (FASD).”
“BACKGROUND The human prenatal brain is very sensitive to the toxic effects of ethanol , but very little information is available concerning the conversion of ethanol to the highly cytotoxic metabolite, acetaldehyde, in that organ.”
Alcoholism, clinical and experimental research • 1998 | View Paper
“Further, the pattern of dentate granule cell axonal projections to hippocampal CA3 pyramidal neurons is altered in rats exposed to ethanol prenatally.”
“The total number of kindling stimulations required to exhibit class 1 through class 5 motor seizures was significantly greater in the rats exposed to ethanol prenatally.”
“Covariate-adjusted comparisons showed that youths prenatally exposed to alcohol exhibited enhanced cognitive functioningcomparedwith thoseborn to abstainers (although, similar to all behavioral outcomes, not of a magnitude that is clinically significant).”
The American journal of psychiatry • 2020 | View Paper
“Children prenatally exposed to alcohol or early life trauma (ELT) are at higher risk of impairment of these skills and may require intervention to address self-regulation deficits.”