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Last Updated: 2 years ago

Possible Interaction: Ethanol and Pregnanolone

supplement:

Ethanol

Research Papers that Mention the Interaction

When administered with ethanol , 1 and 3.2 mg/kg of pregnanolone enhanced the discriminative stimulus effects of small ethanol doses more in saline-treated adolescents than in ethanol-treated adolescents.
Pharmacology Biochemistry and Behavior  •  2009  |  View Paper
Acute ethanol administration induces a dose- and time-dependent increase in brain concentration of the neuroactive steroid allopregnanolone.
Brain Research Reviews  •  2003  |  View Paper
Chronic exposure to ethanol resulted in a decrease in muscimol-stimulated 36Cl- flux and a decrease in modulation of that flux by ethanol, flunitrazepam, methyl-6,7-4-dimethoxy-4-ethyl-beta-carboline-3-carboxylate and pregnanolone without any change in the modulation by pentobarbital or zinc.
The Journal of pharmacology and experimental therapeutics  •  1998  |  View Paper
Finally, under the multiple schedule, noncontingent injections of ethanol (0.32-1.8 g/kg), DHEA (10-100 mg/kg), and pregnanolone (1.8-32 mg/kg) dose-dependently decreased food- and ethanol-maintained responding and the dose of ethanol presented.
Further, we have shown that two neurosteroids, dehydroepiandrosterone (DHEA) and pregnanolone , can readily decrease ethanol self-administration in males.
Alcohol  •  2019  |  View Paper
BACKGROUND Ethanol (EtOH) administration increases brain allopregnanolone levels in rats, and this increase contributes to sensitivity to EtOH's behavioral effects.
Alcoholism, clinical and experimental research  •  2014  |  View Paper
LTP block was enhanced at lower ethanol concentrations in the presence of (3α5α)‐3‐hydroxypregnan‐20‐one , a GABAAR‐potentiating neurosteroid, suggesting that neurosteroids may be important contributors to the effects of ethanol on LTP.
The European journal of neuroscience  •  2007  |  View Paper
The ability of epiallopregnanolone to antagonize the discriminative stimulus or rate-altering effects of ethanol or alphaxalone was also assessed.
Alcoholism, clinical and experimental research  •  2005  |  View Paper
Consumption of ethanol significantly increased brain allopregnanolone levels in male but not female mice, compared with animals drinking water, but did not alter plasma corticosterone levels.
Neuroscience  •  2004  |  View Paper
Similarly, the GABA(A) receptor positive modulators, pregnanolone , chlordiazepoxide, and pentobarbital exhibited TD(50)s of 20.8, 4.6, and 29.7 mg/kg, respectively, when administered alone and 2.7, 0.3, and 11.4 mg/kg, respectively, when administered in the presence of ethanol.
European journal of pharmacology  •  1999  |  View Paper
PE, PS, DHEA, DHEAS, and PA were also capable of blocking the memory-impairing effect of 0.5 g/kg ethanol.
Pharmacology Biochemistry and Behavior  •  1996  |  View Paper