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Last Updated: 3 years ago

Possible Interaction: Ethanol and Prazosin



Research Papers that Mention the Interaction

When prazosin was administered concomitantly with the first opportunity to drink alcohol , it abolished acquisition of alcohol drinking.
Alcoholism, clinical and experimental research  •  2013  |  View Paper
The highest dose of prazosin also increased the latency to first response for alcohol and decreased alcohol intake.
The specificity of prazosin in attenuating the initiation of alcohol- but not sucrose-seeking suggests that this effect is not because of prazosin-induced motor-impairment or malaise.
Alcoholism, clinical and experimental research  •  2012  |  View Paper
At 48 h, hearts of animals given prazosin and ethanol were heavier than those given ethanol alone.
Hearts of animals given the combined treatment of ethanol and prazosin showed cardiomegaly at 24 h, when there was an increase of about 20% in proportional heart weight, an increase that persisted through the remaining 3 days of the study.
In contrast, concurrent treatment with prazosin enhanced the loss of medullary catecholamines and noradrenaline from hearts of rats given ethanol , while it had no such effects in controls.
The results of the study show that prazosin can enhance effects of ethanol on the peripheral sympathetic nervous system.
Canadian journal of physiology and pharmacology  •  1989  |  View Paper
Comparing the depression of these agonist dose-responses by ethanol to the depression by the receptor blockers, verapamil, prazosin and saralasin, suggests that ethanol may act like an alpha 1-adrenoceptor blocker.
European journal of pharmacology  •  1988  |  View Paper