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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“When prazosin was administered concomitantly with the first opportunity to drink alcohol , it abolished acquisition of alcohol drinking.”
Prazosin reduces alcohol drinking throughout prolonged treatment and blocks the initiation of drinking in rats selectively bred for high alcohol intake.“The highest dose of prazosin also increased the latency to first response for alcohol and decreased alcohol intake.”
“The specificity of prazosin in attenuating the initiation of alcohol- but not sucrose-seeking suggests that this effect is not because of prazosin-induced motor-impairment or malaise.”
“At 48 h, hearts of animals given prazosin and ethanol were heavier than those given ethanol alone.”
“Hearts of animals given the combined treatment of ethanol and prazosin showed cardiomegaly at 24 h, when there was an increase of about 20% in proportional heart weight, an increase that persisted through the remaining 3 days of the study.”
“In contrast, concurrent treatment with prazosin enhanced the loss of medullary catecholamines and noradrenaline from hearts of rats given ethanol , while it had no such effects in controls.”
“The results of the study show that prazosin can enhance effects of ethanol on the peripheral sympathetic nervous system.”
“Comparing the depression of these agonist dose-responses by ethanol to the depression by the receptor blockers, verapamil, prazosin and saralasin, suggests that ethanol may act like an alpha 1-adrenoceptor blocker.”
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