Possible Interaction: Ethanol and Potassium Chloride

“Similarly, ethanol caused a dose-dependent reduction of [Ca2+]i transient amplitude in control samples when depolarization was elicited by 100 mM KCl (p < 0.01).”

“ Ethanol significantly attenuated the contractions to phenylephrine and KCl.”

“ Alcohol decreases cytosolic calcium and contractility after KCl and noradrenaline, as compared with controls.”

“The mean values (±S.E.M.) of fluorescence ratios (F340/380) evoked by KCl were significantly lower by about 70% after alcohol , in relation to control.”

“The amplitude of Ca2+ transients elicited specifically in axonal growth cones by focal application of KCl was also inhibited by acute exposure to moderate-to-high concentrations of ethanol (43 or 87 mM), whereas a lower concentration (22 mM) had no effect.”

“At concentrations <50%, ethanol enhanced responses to KCl and NaCl, while at ethanol concentrations >50%, those CT responses were inhibited.”

“Pretreatment with ethanol (400 mM) caused significant decrease of 45Ca2+ uptake induced by KCl when compared to the control.”

“On the other hand, a higher concentration (200 mM) of ethanol significantly inhibited the contractile responses to PDBu, KCl , Ca2+ ionophore A23187 and BaCl2.”

“We now show that ethanol inhibits this trophic effect of NMDA, i.e., promotes apoptosis, and also inhibits the NMDA‐induced increase in intracellular Ca2+ concentration in cells grown in 5 mM KCl.”

“The depolarizing agent potassium chloride (KG, 80 mm) produced less peak active tension in the fundus of ethanol‐fed rats (P < 0.01).”

“In vitro pretreatment of the strips with ethanol at a concentration of over 50 mM significantly attenuated the reactivity and sensitivity of contractile responses to KCl , acetylcholine and histamine in a concentration-dependent manner.”