Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Ethanol and Polyunsaturated Fatty Acids

Research Papers that Mention the Interaction

These results suggest that genetic variation influencing long-chain polyunsaturated fatty acid levels may be important abuse liability loci, and that dietary polyunsaturated fatty acids may be an important environmental modulator of the behavioral response to ethanol.
PloS one  •  2014  |  View Paper
Since diets rich in polyunsaturated fatty acids are a requirement for the development of alcoholic liver disease, we hypothesized that polyunsaturated fatty acids could synergize with ethanol to promote Kupffer cell activation and TNFα production, hence, contributing to liver injury.
American journal of physiology. Gastrointestinal and liver physiology  •  2012  |  View Paper
PGs, LXs, resolvins, and NPD1 precursor supplies are limited; therefore, when ethanol consumption is substantial, tissue concentrations of PUFAs decline, leading to a fall in the synthesis of various PGs, LXs, resolvins, and NPD1.
PLoS medicine  •  2006  |  View Paper
The ingestion of polyunsaturated fatty acids can also increase the damaging effects of alcohol on the liver, as has been demonstrated in rats subjected to continuous intragastric infusion of alcohol.
Nutrition  •  1999  |  View Paper
We hypothesized that alcohol could stimulate the metabolism of this polyunsaturated fatty acid to bioactive products.
Advances in alcohol & substance abuse  •  1988  |  View Paper
Dietary lipids were unrelated to risk, but polyunsaturated fat intake appeared to modify the effects of alcohol and toenail selenium on melanoma risk.
American journal of epidemiology  •  2006  |  View Paper
Alcohol influences the intake and metabolism of several nutrients including long-chain polyunsaturated fatty acids (LC-PUFAs).
Pediatrics  •  2005  |  View Paper
CONCLUSIONS These results suggest that a high intake of al ohol an d a decreased P/S ra tio contribute to the risk of glucose intolerance in contemporary Japanese.
Journal of epidemiology  •  2003  |  View Paper
The presence of ethanol in the perfusate was also associated with a significant reduction (P<….05) in the clearance of H2(18)O. These results suggest that the presence of ethanol at a concentration of 2mg/ml may reduce the availability of polyunsaturated fatty acids to the developing fetus.
The British journal of nutrition  •  2002  |  View Paper
In the hepatoma cells HepG2, ethanol decreases the biosynthesis of LC-PUFA while potentiating the incorporation of acetate into cholesterol.
Prostaglandins, leukotrienes, and essential fatty acids  •  1997  |  View Paper
Show More