Possible Interaction: Ethanol and Polyphenols

“A mixture of polyphenols in amounts found in red wine equivalent to 0.2 g/L ethanol and 0.05 g/L ethanol inhibited thiobarbituric acid-reactive substance production from LDL by 91.7 and 45.9%, respectively, compared with ethanol controls (P < 0.01).”

“Thus, an interaction between ethanol and polyphenols at specific concentrations could reduce oral ester persistence, and likely the fruity character of wines.”

“The addition of ethanol can reduce process temperatures and retain extraction efficiencies, but the ethanol may reduce the recovery of polyphenols in the subsequent purification stage, affecting the antioxidant properties of the extracts.”

“Moreover, the unfavorable effect of ethanol on blood pressure control seems to be counterbalanced by polyphenol protective effects.”

“Such different effects could be explained by the ethanol antagonising potential of other drink components, such as polyphenols , abundant in red wine and scarce in spirits.”

“Apo B100 production was significantly attenuated by 30% in cells incubated with alcoholized red wine, suggesting that the alcohol was masking the effect of red wine polyphenolics.”

“There is evidence that the polyphenolic antioxidants, especially those extracted from grape skin and seed, may protect the brain from neuronal damage due to chronic ethanol administration.”

“HPLC analysis showed that the endo-polyphenol production of the crude ethanol extracts was significantly higher than that of the control.”

“These results suggest that AP exerts a protective effect against chronic ethanol induced memory impairment through improving the oxidative stress in the hippocampus.”

“Alcoholic fatty liver was observed in the group fed the ethanol diet but not in those fed the ethanol plus polyphenol diets.”

“As a result, fatty liver was observed not only in the ethanol group but also with the ethanol plus polyphenol groups.”