Possible Interaction: Ethanol and Polypeptides

“The ethanol pretreatment dramatically increased the passive fluxes of both polypeptides , and iontophoresis produced further enhancements in their fluxes.”

“ Chronic ethanol feeding reduced myofiber size and mRNA expression of IGF-1 polypeptide , insulin, IGF-1, and IGF-2 receptors, IRS-1, and IRS-2.”

“ CE administration resulted a down-regulation of polypeptide levels of the delta-subunit of GABA(A) receptors in the rat cerebellum and hippocampus, whereas there were no changes in the delta-subunit polypeptide levels in the rat cerebral cortex.”

“ Chronic ethanol exposure, in vivo and in vitro, increases polypeptide levels of NR1 subunit, the key subunit of functional NMDA receptors.”

“The polypeptide levels of mGluR5s and NR1 and NR2B subunits of NMDARs were all increased after ethanol exposure; however, the increase in mGluR5s did not achieve statistical significance.”

“ Chronic ethanol consumption decreases the synthesis of all 13 polypeptides encoded by the hepatic mitochondrial genome.”

“Two scrambled NAP peptides (ASPNQPIV and PNIQVASP) were not antagonists at concentrations as high as 10−7 M. Thus, two structurally unrelated classes of compounds, alcohols and small polypeptides , share two common actions: antagonism of ethanol inhibition of L1-mediated cell adhesion and prevention of ethanol teratogenesis.”

“For example, alpha 1 and alpha 2 subunit mRNA and polypeptide levels have been shown to decrease with chronic ethanol exposure.”

“Previous investigations have shown that chronic ethanol exposure elicits alterations in mRNA and polypeptide levels for several abundant GABAA receptor subunits.”

“ Chronic ethanol treatment increased the levels of both of these polypeptides in cerebral cortex.”

“Taken together, chronic ethanol administration produced an upregulation of the beta-subunit mRNA and the polypeptide expression of these subunits in rat cerebral cortex.”

“Since chronic ethanol administration reduces alpha 1 subunit mRNA and polypeptide levels, we investigated whether alterations in [3H]zolpidem binding would also be detected.”