Possible Interaction: Ethanol and Piracetam

“ Piracetam reduced the intensity of withdrawal behavior in mice that had been exposed to ethanol for 4 days.”

“An experimental study of pyracetam (2-pyrrolidonacetamide) showed it capable to mitigate some behavioral and toxic manifestations of the action exerted by alcohol in tests on mice and rats, such as those of the "open field", "conflict situation", "rotating rod" and righting reflex.”

“Administration with Pir significantly increased long-term potentiation and protected hippocampus neurons from EtOH neurotoxicity.”

“ Pir could decrease the expression of LC3-II and Beclin-1 induced by EtOH , and increase the phosphorylation of mTOR and reduce the phosphorylation of Akt, which suggested that the protective effect of Pir was involved in regulation of autophagic process and mTOR/Akt pathways.”

“Structural GABA-analogues - citrocard (50 mg/kg), phenibut (50 mg/kg) and pyracetam (200 mg/kg) prevented injurious action of alcohol.”

“The nootropic drugs, piracetam and N-methyl-D-glucamine, given orally significantly reduced impairment of acquisition induced by EtOH.”

“ Piracetam , lithium hydroxybutyrate, litonit and new oxypyridine derivative 3-OP given in combination with ethanol prevented the development of SDL and reduced an already formed SDL.”

“ Piracetam , MGO and DHET reduce the ethanol drinking in ethanol-preferring mice.”

“Single administration of piracetam did not change the effects of ethanol, while when given prolongly with ethanol piracetam attenuated the effects of ethanol.”