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Last Updated: a month ago

Possible Interaction: Ethanol and Pimonidazole

supplement:

Ethanol

Research Papers that Mention the Interaction

After chronic enteral alcohol, pimonidazole binding increases twofold.
The American journal of physiology  •  1998  |  View Paper
Ethanol feeding also significantly increased pimonidazole adducts in pancreas approximately 2-fold (1 or 3 weeks of ethanol produced similar values).
Archives of biochemistry and biophysics  •  2003  |  View Paper
Ethanol increased hepatic pimonidazole binding about 3-fold, indicating that ethanol led to hypoxia in fatty grafts.
The Journal of pharmacology and experimental therapeutics  •  1999  |  View Paper
Following one large dose of EtOH or chronic enteral EtOH for 1 month, pimonidazole binding was increased significantly in pericentral regions of the liver lobule, which was diminished with GdCl3.
Journal of gastroenterology and hepatology  •  1998  |  View Paper
Ethanol also increased pimonidazole binding significantly at 7 days, long before inflammation and necrosis could be detected.
Ethanol treatment significantly increased both the extent and number of cells that stained positive for pimonidazole compared with control animals given an enteral diet without ethanol.
Hepatology  •  1997  |  View Paper
To clarify this important point, female Sprague-Dawley rats (100-125 g) simultaneously received pimonidazole (120 mg/kg ip), a 2-nitroimidazole hypoxia marker, …), which increase hepatic oxygen uptake dramatically and elevate ethanol metabolism (swift increase in alcohol metabolism) in 2-3 h. After 2 h, ethanol … bound pimonidazole ….
The American journal of physiology  •  1996  |  View Paper
After chronic enteral alcohol, pimonidazole binding increases twofold.
American journal of physiology. Gastrointestinal and liver physiology  •  1998  |  View Paper
Following one large dose of EtOH or chronic enteral EtOH for 1 month, pimonidazole binding was increased significantly in pericentral regions of the liver lobule, which was diminished with GdCl3.
Journal of gastroenterology and hepatology  •  1998  |  View Paper