supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Ethanol
drug:
Physostigmine
Research Papers that Mention the Interaction
“Many years elapsed before anyone tested physostigmine for possible antagonistic effects against other sedative type drugs, such as ethanol.”
“ Physostigmine given before but not after massive doses of ethanol (4.5 g kg−1) did seem to shorten sleeping time and to reduce death of mice, an observation that led to the conclusion that ethanol might inhibit acetylcholine release or function2,3.”
Dissociation of EEG and behavioural effects of ethanol provide evidence for a noncholinergic basis of intoxication“Pre-test intra-CA1 injection of physostigmine (2.5 and 5 microg/mouse, intra-CA1) or nicotine (0.3 and 0.5 microg/mouse, intra-CA1) improved pre-training ethanol (1g/kg)-induced retrieval impairment.”
Ethanol state-dependent memory: Involvement of dorsal hippocampal muscarinic and nicotinic receptors“A physostigmine dose of 0.5 mg/kg combined with the sublethal dose of ethanol produced death in a large percentage of mice.”
“ Physostigmine , in an optimum dose of 0.1 mg/kg given at the same time as 4.5 g/kg ethanol , significantly shortened sleeping time when compared to controls given saline and ethanol.”
“Stressing the animals in the experiment with the combination of 0.06 mg/kg of physostigmine with ethanol was reflected in a significant change in the influence on correct response latencies.”
“At 16 days, physostigmine enhanced the activity of the alcohol group , had no effect on the sucrose group, but depressed the activity of the chow group.”
“The frequency analysis of tremor in ethanol withdrawn rats treated with physostigmine showed that the rats trembled at two frequencies, 6-7 Hz and 13 Hz.”
“ Physostigmine pretreatment augmented the depressant effect of alcohol on the early components P1 and N1, while attenuating alcohol's influence on components P2 and P3.”
“If these neuronal effects are associated with CNS depression, then administration of a cholinesterase inhibitor physostigmine ) with ethanol should result in antagonism of this CNS depression.”
“Our findings indicate an antagonism between ethanol and physostigmine ; the shortened sleep latency observed in animals receiving ethanol was reversed to control levels with administration of physostigmine.”
“ Physostigmine sulphate , in doses of 0.05–0.3 mg/kg given intravenously 1–2 min after ethanol , reversed the synchrony.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback