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Last Updated: 2 years ago

Possible Interaction: Ethanol and Physostigmine

supplement:

Ethanol

Research Papers that Mention the Interaction

Many years elapsed before anyone tested physostigmine for possible antagonistic effects against other sedative type drugs, such as ethanol.
Physostigmine given before but not after massive doses of ethanol (4.5 g kg−1) did seem to shorten sleeping time and to reduce death of mice, an observation that led to the conclusion that ethanol might inhibit acetylcholine release or function2,3.
Nature  •  1974  |  View Paper
Pre-test intra-CA1 injection of physostigmine (2.5 and 5 microg/mouse, intra-CA1) or nicotine (0.3 and 0.5 microg/mouse, intra-CA1) improved pre-training ethanol (1g/kg)-induced retrieval impairment.
Neurobiology of Learning and Memory  •  2008  |  View Paper
A physostigmine dose of 0.5 mg/kg combined with the sublethal dose of ethanol produced death in a large percentage of mice.
Physostigmine , in an optimum dose of 0.1 mg/kg given at the same time as 4.5 g/kg ethanol , significantly shortened sleeping time when compared to controls given saline and ethanol.
Agents and Actions  •  2005  |  View Paper
Stressing the animals in the experiment with the combination of 0.06 mg/kg of physostigmine with ethanol was reflected in a significant change in the influence on correct response latencies.
Acta Universitatis Palackianae Olomucensis Facultatis Medicae  •  1989  |  View Paper
At 16 days, physostigmine enhanced the activity of the alcohol group , had no effect on the sucrose group, but depressed the activity of the chow group.
Neurotoxicology and teratology  •  1988  |  View Paper
The frequency analysis of tremor in ethanol withdrawn rats treated with physostigmine showed that the rats trembled at two frequencies, 6-7 Hz and 13 Hz.
Pharmacology Biochemistry and Behavior  •  1985  |  View Paper
Physostigmine pretreatment augmented the depressant effect of alcohol on the early components P1 and N1, while attenuating alcohol's influence on components P2 and P3.
Alcohol  •  1984  |  View Paper
If these neuronal effects are associated with CNS depression, then administration of a cholinesterase inhibitor physostigmine ) with ethanol should result in antagonism of this CNS depression.
Our findings indicate an antagonism between ethanol and physostigmine ; the shortened sleep latency observed in animals receiving ethanol was reversed to control levels with administration of physostigmine.
Substance and alcohol actions/misuse  •  1982  |  View Paper
Physostigmine sulphate , in doses of 0.05–0.3 mg/kg given intravenously 1–2 min after ethanol , reversed the synchrony.
Neuropharmacology  •  1976  |  View Paper