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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Ethanol
drug:
Phospholipids
Research Papers that Mention the Interaction
“However, the ethanol within ethosomes increases phospholipid membrane fluidity and permeability, leading to drug leakage during storage.”
Co-hybridized composite nanovesicles for enhanced transdermal eugenol and cinnamaldehyde delivery and their potential efficacy in ulcerative colitis.“ Alcohol also undergoes chemical coupling to membrane phospholipids and disrupts organization of tight junctions, leading to nuclear translocation of β-catenin and ZONAB, which may contributes to regulation of genes involved in proliferation, invasion and metastasis.”
“Of note, the nonoxidative reaction of ethanol with phospholipids and fatty acids yields bioactive compounds that affect cellular signaling pathways and organelle function and may contribute to ethanol toxicity.”
“The incorporation of additives, such as anionic surfactants and ethanol , can fluidize the phospholipid bilayers , thus increasing the depths to which liposomes can penetrate the intercellular pathways of the skin.”
“Changes in membrane lipid composition that are consistent with decreased fluidity or with resistance to ethanol including increases in membrane cholesterol, reductions in the double bond index of phospholipid acyl chains, and increases in anionic phospholipids , have been reported during ethanol treatment.”
“The results present evidence that chronic ethanol treatment results in an increase in the acidic phospholipids in brain membranes.”
“We suggest that an adaptive change in the phospholipid composition leads to structural alterations, which result in increased resistance to disruption of mitochondrial membranes by ethanol.”
“The … alcohol to rat and human liver slices depressed the formation of 14 CO 2 from palmitic acid-1- … C, oleic acid-1- 14 C and linoleic acid-1- 14 C. The esterification to triglycerides and phospholipids was increased and the formation of …-keto acids was decreased by alcohol.”
“This metabolism of ethanol can induce the oxidation of the fatty acids in phospholipids , and the bioactive aldehydes produced are known to be associated with neurotoxicity and neurodegeneration.”
“ Ethanol is known to disrupt phospholipid packing and promote membrane hemifusion at lipid bilayers.”
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