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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
supplement:
Phosphatidylinositol 4,5-Diphosphate
Research Papers that Mention the Interaction
“Here, we used specialized biophysical tools and discovered that ethanol associates directly with the GIRK channel, leading to enhanced interaction with a membrane phospholipid phosphatidylinositol 4,5-bisphosphate and activation of the channel.”
Molecular mechanism underlying ethanol activation of G-protein–gated inwardly rectifying potassium channels“ Ethanol (50-200 mM) added to the incubation system showed a dose-dependent decrease in labeling of PIP2 , but not PIP or PA.”
Effects of ethanol on phosphorylation of lipids in rat synaptic plasma membranes.“Moreover, the stimulation of PtdInsP kinase by ethanol , which accompanies PLC activation, was refractory to okadaic acid treatment.”
“Addition of ethanol at and above 10 mM concentration in vitro significantly decreased the incorporation of 32Pi into both phosphatidylinositol-4-phosphate and phosphatidylinositol-4,5 bis-phosphate by the isolated cells.”
“In contrast, ethanol , caused 1.5-fold increase in IP1 and PIP2 , and 35% decrease in PIP, 47% decrease in IP2 and 38% decrease in IP3.”
“In 32P-labeled hepatocytes addition of ethanol caused a small (5-7%) decrease in the level of [32P]phosphatidylinositol 4,5-bisphosphate and a 10-15% increase in [32P]phosphatidylinositol 4-phosphate and [32P]phosphatidic acid.”
“Even though our studies revealed that the inhibitory effects of ethanol on the Kv7.2/7.3 channel was diminished by the increase of plasma membrane phosphatidylinositol 4,5-bisphosphate (PI (4,5)P2), the molecular mechanism of ethanol on Kv7.2/7.3 channel inhibition remains unclear.”
“Even though our studies revealed that the inhibitory effects of ethanol on the Kv7.2/7.3 channel was diminished by the increase of plasma membrane phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), the molecular mechanism of ethanol on Kv7.2/7.3 channel inhibition remains unclear.”
Ethanol inhibits Kv7.2/7.3 channel open probability by reducing the PI(4,5)P2 sensitivity of Kv7.2 subunit“This dynamic interaction with PIP2 may explain the intrinsic low open probability of GIRK channels and the mechanism underlying activation by G protein G&bgr;&ggr; subunits and ethanol.”
“The results indicate that bradykinin-induced breakdown of phosphatidylinositol 4,5-bisphosphate adapts to the effects of ethanol , after long-term treatment.”
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