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Last Updated: 2 years ago

Possible Interaction: Ethanol and Phosphatidylinositol 4,5-Diphosphate

Research Papers that Mention the Interaction

Here, we used specialized biophysical tools and discovered that ethanol associates directly with the GIRK channel, leading to enhanced interaction with a membrane phospholipid phosphatidylinositol 4,5-bisphosphate and activation of the channel.
Proceedings of the National Academy of Sciences  •  2013  |  View Paper
Ethanol (50-200 mM) added to the incubation system showed a dose-dependent decrease in labeling of PIP2 , but not PIP or PA.
Alcoholism, clinical and experimental research  •  1996  |  View Paper
Moreover, the stimulation of PtdInsP kinase by ethanol , which accompanies PLC activation, was refractory to okadaic acid treatment.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement  •  1994  |  View Paper
Addition of ethanol at and above 10 mM concentration in vitro significantly decreased the incorporation of 32Pi into both phosphatidylinositol-4-phosphate and phosphatidylinositol-4,5 bis-phosphate by the isolated cells.
Indian journal of biochemistry & biophysics  •  1991  |  View Paper
In contrast, ethanol , caused 1.5-fold increase in IP1 and PIP2 , and 35% decrease in PIP, 47% decrease in IP2 and 38% decrease in IP3.
Biochemistry international  •  1990  |  View Paper
In 32P-labeled hepatocytes addition of ethanol caused a small (5-7%) decrease in the level of [32P]phosphatidylinositol 4,5-bisphosphate and a 10-15% increase in [32P]phosphatidylinositol 4-phosphate and [32P]phosphatidic acid.
The Journal of biological chemistry  •  1987  |  View Paper
Even though our studies revealed that the inhibitory effects of ethanol on the Kv7.2/7.3 channel was diminished by the increase of plasma membrane phosphatidylinositol 4,5-bisphosphate (PI (4,5)P2), the molecular mechanism of ethanol on Kv7.2/7.3 channel inhibition remains unclear.
Even though our studies revealed that the inhibitory effects of ethanol on the Kv7.2/7.3 channel was diminished by the increase of plasma membrane phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), the molecular mechanism of ethanol on Kv7.2/7.3 channel inhibition remains unclear.
BMB reports  •  2021  |  View Paper
This dynamic interaction with PIP2 may explain the intrinsic low open probability of GIRK channels and the mechanism underlying activation by G protein G&bgr;&ggr; subunits and ethanol.
The Journal of general physiology  •  2017  |  View Paper
The results indicate that bradykinin-induced breakdown of phosphatidylinositol 4,5-bisphosphate adapts to the effects of ethanol , after long-term treatment.
Neuropharmacology  •  1992  |  View Paper