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Possible Interaction: Ethanol and Phosphatidic Acid



Research Papers that Mention the Interaction

Furthermore, in carbachol‐stimulated cells, ethanol increased the formation of phosphatidylethanol and inhibited the formation of PA.
Journal of neurochemistry  •  2004  |  View Paper
Ethanol inhibited the accumulation of endogenous PA and calcium mobilization, indicating that activation of membrane phospholipase D plays a role in PA‐mediated Ca2+ influx.
Journal of cellular biochemistry  •  2000  |  View Paper
Ethanol , which competitively lowers phosphatidic acid ( PA ) production, caused dose‐dependent inhibition of superoxide (O2 ‐) generation after hyphal stimulation but altered neither baseline‐unstimulated O2 ‐ production nor responses to phorbol myristate acetate.
Journal of leukocyte biology  •  1995  |  View Paper
In cells labeled with L-lyso-3-PC 1-[1- 14C]palmitoyl, PLD but not IL-4, increased the production of phosphatidic acid (PA) and phosphatidyl-ethanol when pretreated with ethanol.
The Journal of experimental medicine  •  1994  |  View Paper
Inhibition of phosphatidic acid formation by wortmannin or ethanol reduced the microcrystal-stimulated production of superoxide anions.
Arthritis and rheumatism  •  1993  |  View Paper
In both cases, there was a concomitant rise of diacylglycerol (DG), and the PA accumulation was suppressed by ethanol at the expense of labeling of PEt.
Biochimica et biophysica acta  •  1993  |  View Paper
As primary alcohols such as ethanol and 1-butanol were shown to inhibit the phospholipase D (PLD)-mediated formation of PA , a mitogenic lipid messenger, we tested their effects on ceramide formation.
Ethanol reduces the PA :ceramide ratio in fetal astrocytes, a mechanism which likely participates in ethanol-induced glial apoptosis during brain development.
BMC pharmacology  •  2005  |  View Paper
Concomitantly, ethanol caused the formation of phosphatidylethanol (PEth) by phospholipase D (PLD) and reduced PLD‐mediated formation of phosphatidic acid (PA).
International Journal of Developmental Neuroscience  •  2000  |  View Paper
Since the involvement of PLD activation in the early stages of pancreatic regeneration was postulated, our results suggest that chronic ethanol feeding can influence this process by decrease of PA production, probably because of the inhibition of hydrolytic PLD activity in the presence of ethanol.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  1999  |  View Paper
J. 285, 395-400), the presence of ethanol decreases the α-thrombin-induced production of phosphatidic acid without affecting the induced increase in nuclear diglyceride, indicating that the increase in nuclear PLD activity is responsible for the effect on phosphatidic acid, but not that on diglyceride.
The Journal of Biological Chemistry  •  1997  |  View Paper
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