Possible Interaction: Ethanol and Phenytoin

“In conclusion, increase in serum GGT activity occurs 90% of patients on long-term phenytoin therapy , most often to moderate but occasionally to high levels, and this rise in GGT activity is accentuated by regular consumption of alcohol.”

“Highly bound drugs with low intrinsic hepatic clearance are among the most commonly reported to have their kinetics altered by ethanol (e.g. benzodiazepines, phenytoin , tolbutamide and warfarin).”

“Analysis of membrane order using the environment-sensitive fluorescent probe DPH revealed decrease in membrane order with increasing PEtOH concentration, as evident from reduction in rotational correlation time of the probe.”

“As the ITM stage of memory … of Na(+)/K(+) ATPase, and as DPH is a facilitator of Na(+)/K(+) ATPase activity … that the combined effect of OT and ethanol exposure is by interfering with Na(+)/K(+) ATPase activity, thus … memory in the period from 10 min following aversant training.”

“The investigated psychotropic drugs did not … but given in combination with ethanol caused significant decline of PD: diazepam (0.4 mg/kg) by 58%, chlorpromazine (6.… 59%, imipramine (2 mg/kg) by 48%, amitriptyline (4 mg/kg) by 49%, phenytoin (4 mg/kg) by 53%, … mg/kg) by 58%.”

“In the case of 14C-pentobarbital and 14C-diphenylhydantoin after a short period of distribution disappearance of radioactivity was faster under the influence of ethanol , whereas radioactivity in liver tissue was increased.”

“With increasing concentrations of ethanol , there were substantial decreases in the adsorption of ACET, PHB, and PHY to charcoal.”