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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Phenylephrine
Research Papers that Mention the Interaction
“The pressor responsiveness was also influenced differently by ethanol depending on the method of injecting phenylephrine.”
Effect of acute ethanol administration on the baroreceptor reflex control of heart rate in normotensive human volunteers.“In the presence of ethanol, phenylephrine stimulated phosphatidylethanol formation in α1A- and α1B-adrenoceptor-expressing cells time and concentration dependently but only weakly and inconsistently in α1D-adrenoceptor-expressing cells.”
“Pretreatment with ethanol dose-dependently increased the potency of phenylephrine to induce vasoconstriction 4-fold (p<0.01).”
Effects of ethanol and ethanol metabolites on intrinsic function of mesenteric resistance arteries“Intra‐pVTA administration of phenylephrine (alpha‐1 adrenoceptor agonist) increased ethanol self‐administration, while prazosin and disulfiram (agents that reduce noradrenergic tone) produced opposite effects.”
“Moreover, combined treatment with testosterone and ethanol reduced the pressor response to the selective α1-adrenoceptor agonist phenylephrine.”
“ Ethanol significantly attenuated the contractions to phenylephrine and KCl.”
“Prazosin (0.1; 0.5 and 1.0 mg/kg) and phenylephrine (1.0 and 2.0 mg/kg) administration blocked the expression of behavioral sensitization to ethanol.”
“The group treated with ethanol showed a decrease in vas deferens contractility to noradrenaline, phenylephrine , and barium, by less than 20%.”
“ Chronic ethanol consumption increased the contractile response to phenylephrine of endothelium‐intact and denuded rat aortic rings from rats pretreated with ethanol for 2 or 6 weeks.”
“Six weeks' ethanol consumption enhanced the contractile response to phenylephrine of endothelium‐intact, but not denuded rat MAB.”
“Vascular responsiveness to the pressor agent phenylephrine was initially enhanced and later on decreased during chronic ethanol intake.”
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