Possible Interaction: Ethanol and Phenylalanine

“Hydroxyl radical scavengers such as ethanol , D-mannitol and dimethylsulfoxide inhibited the phenylalanine oxidation in a dose-dependent fashion.”

“Citric acid, cyclamic acid, D-fructose, D-galactose, D-glucose, hydrogen peroxide, DL-malic acid, L-phenylalanine , saccharin, sodium benzoate, and sucrose show no interferences but ethanol interferes strongly.”

“ Ethanol lowered the concentration of most plasma amino acids (AA) or related compounds in stressed rats (e.g., aspartic acid, threonine, serine, glycine, alanine, valine, tyrosine, phenylalanine , tryptophan).”

“The separate or combined treatment with phenylalanine and leucine, resulted in decreased voluntary consumption of ethanol.”

“Furthermore, in both the ethanol-treated animals and …-fed controls the rate of incorporation of [3H]phenylalanine into total proteins, POMC, beta-lipotropin, and beta … significantly higher on days 8 and 15 after ethanol withdrawal than on the day of ethanol withdrawal (…), suggesting the implication of a nutritional factor.”

“… ethanol … 3H phenylalanine indicated that the content of beta-EPLIR in the incubation medium was increased, the content of the newly biosynthesized 3H-phenylalanine labelled proteins …-lipotropin and beta-endorphin in the neurointermediate lobes extract were not significantly changed by the ethanol treatment, though a small increase was observed.”

“ Chronic ethanol treatment produced a decrease in the arteriovenous differences of Asp, Thr, Arg, Met and Phe , and increased those of Ala, Gln, Gly, Pro and Tyr.”

“We have been able to significantly attenuate both volitional and forced ethanol intake respectively by acute and chronic treatment with hydrocinnamic acid and D-phenylalanine , known carboxypeptidase (enkephalinase) inhibitors.”

“Some amino acids and dipeptides like lysine, tryptophan and glycyl-phenylalanine have an additional stimulatory effect on ethanol absorption which seems unrelated to water movement.”

“ Ethanol was found to enhance plasmid DNA stability and to inhibit the hydroxylation of phenylalanine ; both observations are consistent with the known ability of ethanol to serve as a hydroxyl radical scavenger.”