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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
supplement:
Phenethyl Isothiocyanate
Research Papers that Mention the Interaction
“The formation of keto aldehyde and keto alcohol was inhibited by PEITC in human liver microsomes with IC50 values of 9.5 and 4.6 microM respectively.”
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate.“By contrast, inhibition of aldehyde dehydrogenase with phenethyl isothiocyanate increased the inhibitory effect of ethanol on ureagenic respiration by an additional 60%.”
Ethanol Suppresses Ureagenesis in Rat Hepatocytes“Here we report that rat treatment with DAS and PIC significantly decreased the trapping of hydroxyethyl free radicals in liver microsomes incubated in vitro with ethanol.”
“Microsomal CYP2E1 protein levels induction by ethanol was decreased by PIC ingestion.”
“Similarly, PIC reduced the increase microsomal reduced form of nicotinamide-adenine dinucleotide (NADPH)-dependent lipid peroxidation and p-nitrophenol hydroxylase (PNPH) activity, induced by ethanol feeding.”
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