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Last Updated: 3 years ago

Possible Interaction: Ethanol and Phenethyl Isothiocyanate



Research Papers that Mention the Interaction

The formation of keto aldehyde and keto alcohol was inhibited by PEITC in human liver microsomes with IC50 values of 9.5 and 4.6 microM respectively.
Carcinogenesis  •  1996  |  View Paper
By contrast, inhibition of aldehyde dehydrogenase with phenethyl isothiocyanate increased the inhibitory effect of ethanol on ureagenic respiration by an additional 60%.
The Journal of Biological Chemistry  •  2012  |  View Paper
Here we report that rat treatment with DAS and PIC significantly decreased the trapping of hydroxyethyl free radicals in liver microsomes incubated in vitro with ethanol.
Hepatology  •  1996  |  View Paper
Microsomal CYP2E1 protein levels induction by ethanol was decreased by PIC ingestion.
Similarly, PIC reduced the increase microsomal reduced form of nicotinamide-adenine dinucleotide (NADPH)-dependent lipid peroxidation and p-nitrophenol hydroxylase (PNPH) activity, induced by ethanol feeding.
Hepatology  •  1995  |  View Paper