Possible Interaction: Ethanol and Pentobarbital

“Direct activation of the GABAA receptor by pentobarbital was enhanced by chronic ethanol treatment.”

“Thus, the type of expression/assay system markedly affects the actions of ethanol on GABAA receptors and also influences the actions of muscimol and pentobarbital on this receptor.”

“ Pentobarbital and diazepam completely suppressed ethanol withdrawal reactions.”

“In UChA, but not in the UChB rats, the chronic treatment with ethanol induced tolerance to pentobarbital as shown by the same test.”

“ Ethanol inhibited the uptake in a concentration-dependent manner over the range … to 720 mM. Analysis of the effects of ethanol and pentobarbital on calcium uptake at different temperatures indicated that the drugs did not change … activation energy of the process but shifted the Arrhenius curves toward higher temperatures.”

“6 Animals withdrawn following chronic administration of a number of drugs, barbitone, barbitone/bemegride mixture, Mandrax (methaqualone: diphenhydramine; 10: 1), chlordiazepoxide, nitrazepam, chlorpromazine or ethanol , exhibited a significant tolerance to intracerebroventricularly administered pentobarbitone.”

“ Ethanol ingestion significantly retarded the disappearance of pentobarbital and meprobamate from the blood in human volunteer subjects and rats.”

“In vitro ethanol inhibited aniline, pentobarbital , and benzpyrene hydroxylases.”

“In 15 mM K+, ethanol has no effect by itself but enhances the stimulatory effect of 0.01 mM pentobarbital.”

“It has been shown, for example, that in fatal poisonings involving dextropropoxyphene, amitriptyline, pentobarbitone or chlormethiazole, the presence of ethanol causes a decrease in the concentration of the drug at which a given proportion of fatalities”