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Last Updated: 2 years ago

Possible Interaction: Ethanol and Penicillamine



Research Papers that Mention the Interaction

Pretreatment with DP or LA only prevented GPx activity changes induced by ethanol.
Alcoholism, clinical and experimental research  •  2019  |  View Paper
DP treatment blocked the increase in ethanol responses following the imposed abstinence period.
RationalePrevious experiments in our laboratory have shown that d-penicillamine (DP) (acetaldehyde sequestering agent) is able to block the increase in ethanol consumption observed after a period of imposed deprivation (the so-called alcohol deprivation effect (ADE)), using a non-operant paradigm in Wistar rats.
Psychopharmacology  •  2015  |  View Paper
The nitric oxide synthase inhibitor L-NAME (20 mg kg(-1)) and acetaldehyde sequestering agent D-penicillamine (50 mg kg(-1)) both attenuated the increase in NO levels following ethanol (1 g kg(-1)) administration.
Nitric oxide : biology and chemistry  •  2015  |  View Paper
Our results show that the injection of α-lipoic acid, aminotriazole and d-penicillamine prior to acute EtOH administration effectively blocks the PKA-enhanced response to EtOH in the brain.
Neuroscience Letters  •  2014  |  View Paper
In experiment 1, there were indications that d-penicillamine weakened the reinforcing effects of EtOH and ACD.
In experiment 2, d-penicillamine (40 μg) significantly inhibited appetitive conditioned responses dependent upon EtOH or ACD.ConclusionsAppetitive conditioning was observed when employing either central EtOH or ACD as unconditioned stimuli.
Psychopharmacology  •  2012  |  View Paper
In the plus maze, AT completely blocked and d-penicillamine significantly reduced the anxiolytic properties of ethanol.
Psychopharmacology  •  2008  |  View Paper
D-Penicillamine was found to reduce ethanol intake in a dose-dependent manner.
We also demonstrated that D-penicillamine produced changes in the ingestive and flavor properties of sucrose and ethanol , measured by means of a taste reactivity test.
Behavioural Brain Research  •  2006  |  View Paper
Previous studies from our laboratory have demonstrated that d-penicillamine prevents both behavioral stimulation induced by ethanol and acetaldehyde-produced locomotor depression in mice.
Psychopharmacology  •  2005  |  View Paper
In addition, D-penicillamine was also effective in lowering behavioral locomotion induced by ethanol (1.8 and 2.4 g/kg), without altering spontaneous locomotor activity.
Alcoholism, clinical and experimental research  •  2005  |  View Paper
By administration of D-penicillamine in multiple, divided doses, blood acetaldehyde generated during ethanol metabolism was reduced an average of 70% over an 8 hour period.
Life sciences  •  1977  |  View Paper
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