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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Ethanol
drug:
Penicillamine
Research Papers that Mention the Interaction
“Pretreatment with DP or LA only prevented GPx activity changes induced by ethanol.”
“ DP treatment blocked the increase in ethanol responses following the imposed abstinence period.”
“RationalePrevious experiments in our laboratory have shown that d-penicillamine (DP) (acetaldehyde sequestering agent) is able to block the increase in ethanol consumption observed after a period of imposed deprivation (the so-called alcohol deprivation effect (ADE)), using a non-operant paradigm in Wistar rats.”
“The nitric oxide synthase inhibitor L-NAME (20 mg kg(-1)) and acetaldehyde sequestering agent D-penicillamine (50 mg kg(-1)) both attenuated the increase in NO levels following ethanol (1 g kg(-1)) administration.”
“Our results show that the injection of α-lipoic acid, aminotriazole and d-penicillamine prior to acute EtOH administration effectively blocks the PKA-enhanced response to EtOH in the brain.”
“In experiment 1, there were indications that d-penicillamine weakened the reinforcing effects of EtOH and ACD.”
“In experiment 2, d-penicillamine (40 μg) significantly inhibited appetitive conditioned responses dependent upon EtOH or ACD.ConclusionsAppetitive conditioning was observed when employing either central EtOH or ACD as unconditioned stimuli.”
The role of acetaldehyde in ethanol reinforcement assessed by Pavlovian conditioning in newborn rats“In the plus maze, AT completely blocked and d-penicillamine significantly reduced the anxiolytic properties of ethanol.”
“ D-Penicillamine was found to reduce ethanol intake in a dose-dependent manner.”
“We also demonstrated that D-penicillamine produced changes in the ingestive and flavor properties of sucrose and ethanol , measured by means of a taste reactivity test.”
“Previous studies from our laboratory have demonstrated that d-penicillamine prevents both behavioral stimulation induced by ethanol and acetaldehyde-produced locomotor depression in mice.”
“In addition, D-penicillamine was also effective in lowering behavioral locomotion induced by ethanol (1.8 and 2.4 g/kg), without altering spontaneous locomotor activity.”
“By administration of D-penicillamine in multiple, divided doses, blood acetaldehyde generated during ethanol metabolism was reduced an average of 70% over an 8 hour period.”
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