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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“However a single dose of ethanol given one hour after pargyline administration enhanced the rate of recovery of hepatic GSH.”
Effect of pargyline on hepatic glutathione levels in rats treated acutely and chronically with ethanol.“Elevated blood acetaldehyde was observed when ethanol was given at 15 minutes, 2 or 5 hours after pargyline ; the action of pargyline had largely disappeared after 18 hours.”
“Like other agents which increase 5-HT, pargyline produced a depression in ethanol intake which lasted beyond the time of drug administration.”
Reduction of alcohol selection by pargyline in mice“A low dose of pargyline (10mg/kg) produced significantly higher inhibition of MAO-A in the alcoholised rats, whereas the degree of MAO-B inhibition was the same in both groups.”
“Administration of a large dose of pargyline (60mg/kg) caused total irreversible inhibition of brain monoamine oxidases (MAOs) in both control and alcoholised rats.”
“The irreversible MAO-B inhibitors, pargyline (30 mg/kg) and l-deprenyl (3-10 mg/kg) also decreased responding maintained by ethanol reinforcement; these results are consistent with previous findings that both drugs decreased ethanol intake in mice.”
“Administration of pargyline or Lilly 51641 prior to ethanol treatment (3.0 g/kg) resulted in a significant elevation of blood acetaldehyde.”
“ Ethanol alone (22 mM) had no effect on tritium release; however, with pargyline pretreatment tritium release increased by 13%.”
“ Ethanol , 65 mM, increased spontaneous tritium release by 8% and pargyline , 100 mg/kg b.wt.,”
“After a 20- to 30-min incubation period, pargyline inhibited the control rate of ethanol oxidation by the liver cells, as well as the accelerated rate of ethanol oxidation found in the presence of pyruvate or an uncoupling agent.”
“As compared to animals receiving only ethanol, administration of either-4-methyl-pyrazole or pargyline plus ethanol resulted in more severe damage to mitochondrial respiration and myocardial protein synthesis.”
“Both pargyline and Lilly 51641 reduced ethanol preference; in contrast, nialamide did not affect preference, despite the fact that it inhibited MAO activity by more than 90%.”
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