Possible Interaction: Ethanol and Pantothenic Acid

“On the contrary, in rats fed a diet containing a low-vitamin mixture, consumption of ethanol caused a decrease in the contents of vitamins B₁, B₂ and pantothenic acid in the liver; however, the contents of the other vitamins did not decrease.”

“ Ethanol consumption alters the levels and distribution of pantothenic acid and its metabolic products, an effect that can be counteracted by preloading with pantothenic acid.”

“ Pantothenic acid (200 mg/kg, IP or IV) administered before ethanol intubation completely counteracted the tremor-reducing action of ethanol in two monkeys and partially counteracted it in a third.”

“3 PA concentration in the brain of rats treated with ethanol plus PA for 4 months was three times that of rats treated with ethanol alone.”

“6 Data suggest that chronic ethanol exposure may decrease ACh synthesis by depleting PA , a precursor for the synthesis of acetyl CoA. Acetyl CoA is an essential substrate for ACh synthesis.”

“ACh synthesis in rats with ethanol and PA supplementation was also significantly (P <0.01) higher.”