Possible Interaction: Ethanol and Palmitic Acid

“In parallel, ethanol increased the activity of ACC and suppressed the rate of palmitic acid oxidation.”

“When cells prelabelled with [3H]palmitic acid were stimulated with TPA in the presence of ethanol , an increase of labelled diacylglycerol and phosphatidylethanol in the nuclei was observed.”

“Conversion of [1-14C] palmitic to oleic acid and eicosatrienoic to arachidonic acid were inhibited in 400 mM ethanol treated cells suggesting an inhibition of delta 9 and delta 5 desaturase activity.”

“Treatment of cultured hepatic cells with palmitic acid (a major saturated fatty acid in HSF diet) in the presence of ethanol robustly increased AdipoR2 mRNA expression and enhanced activity of a mouse AdipoR2 promoter.”

“For meconium of the ethanol offspring (n=25 fetuses) compared with the sucrose offspring (n=23 fetuses), the total FAEE concentration was 8-fold higher; and lauric, palmitic , stearic and oleic AEE concentrations were at least 5-fold higher for the ethanol group.”

“ Ethanol administration for a period of 60 days modifies the fatty acid … showed that there was a significant increase in the concentrations of palmitic acid (16:0), stearic acid (18:0), and oleic acid (18:1) in … of palmitoleic (16:1) and arachidonic acid (20:4) were significantly decreased.”

“In addition, ethanol ingestion also decreased significantly (P < 0.01) the proportion of 16:0 and increased 18:0 and 18:1 in hepatic phospholipids, suggesting a perturbation of the de novo fatty acid biosynthesis pathways.”

“At the same time point, ethanol increased radioactivity incorporated into hepatic total lipid and triglyceride, after an injection of [U-14C] palmitic acid , by 76% and 158% respectively.”

“ Ethanol increased the proportion of oleic and decreased the relative amount of palmitic , palmitoleic, and linoleic acids in triglycerides of lung tissue.”

“Oxidation of (1-14C) palmitic acid to 14CO2 in liver is inhibited by 60–70% upon ethanol administration.”