Possible Interaction: Ethanol and Palmitate

“In NG108‐15 rat neuroblastoma × glioma hybrid cells, acute exposure to pharmacologically relevant concentrations of ethanol (25–100 mm) inhibited basal and prostaglandin E1‐stimulated incorporation of palmitate into Gαs.”

“Pretreatment with multiple low-dose ethanol exposures attenuates the apoptotic response to palmitate.”

“In hepatocytes from starved or fed rats, ethanol inhibited total beta-oxidation in the presence of 1.3 mM palmitate by 22% and 25%, respectively.”

“In perfused liver from fed rats, inhibition by ethanol of total beta-oxidation in the presence of 1 mM palmitate was 35%.”

“Preliminary results suggest that the concentrations of palmitate and stearate in superfusate decrease after ethanol administration.”

“ Palmitate (1 mM) increased rates of ethanol oxidation to 95 +/- 8 mumol/g/hr, while octanoate and oleate increased rates to 58 +/- 11 and 68 +/- 15 mumol/g/hr, respectively.”

“ Ethanol caused a 250% increase in the hepatic lactate:pyruvate (L:P) ratio and a 100% increase in the amount of [U-14C] palmitate incorporated into the hepatic lipids when compared with controls.”

“ Palmitate , but not hexanoate, partially inhibited lactate-stimulated ethanol oxidation.”

“ Ethanol , when used in concentrations likely to be achieved in the upper jejunum after moderate drinking, inhibited both palmitate and acetate oxidation, CO2 production and triacylglycerol synthesis, whereas it enhanced the esterification of fatty acid with ethanol.”

“Among the effects of large doses of ethanol on PL classes was a marked relative increase of palmitate incorporation into the phosphatidylserine fraction of both groups and a corresponding decrease in the amount in phosphatidylcholine.”