supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Ethanol
drug:
Paclitaxel
Research Papers that Mention the Interaction
“However, the severe adverse effects of its present formulation (Cremophor EL and ethanol ) and the development of drug resistance by the activation of nuclear factor-κB (NF-κB) reduce the anti-tumor activities of PTX.”
Combined Delivery and Anti-Cancer Activity of Paclitaxel and Curcumin Using Polymeric Micelles.“Very high concentrations of Cremophor EL and ethanol in Taxol have rendered patients to severe side effects.”
“Both DMSO and ethanol increased the Km and decreased the CLint of CYP2C8-mediated paclitaxel hydroxylation in a concentration-dependent manner.”
“However, the Taxol solvent Cremophor EL--ethanol was considerably active alone, whereas paclitaxel formulated in ethanol was less active.”
“When paclitaxel was formulated only in ethanol the effects on the corresponding doxorubicin-resistant sublines were significantly reduced compared with paclitaxel dissolved in ethanol plus cremophor EL.”
“However, Taxol has some severe side effects related to Cremophor EL and ethanol.”
Paclitaxel Nano-Delivery Systems: A Comprehensive Review.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback