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Last Updated: 3 years ago

Possible Interaction: Ethanol and Paclitaxel



Research Papers that Mention the Interaction

However, the severe adverse effects of its present formulation (Cremophor EL and ethanol ) and the development of drug resistance by the activation of nuclear factor-κB (NF-κB) reduce the anti-tumor activities of PTX.
Journal of biomedical nanotechnology  •  2015  |  View Paper
Very high concentrations of Cremophor EL and ethanol in Taxol have rendered patients to severe side effects.
Journal of biomedical nanotechnology  •  2013  |  View Paper
Both DMSO and ethanol increased the Km and decreased the CLint of CYP2C8-mediated paclitaxel hydroxylation in a concentration-dependent manner.
Drug Metabolism and Disposition  •  2007  |  View Paper
However, the Taxol solvent Cremophor EL--ethanol was considerably active alone, whereas paclitaxel formulated in ethanol was less active.
British Journal of Cancer  •  1995  |  View Paper
When paclitaxel was formulated only in ethanol the effects on the corresponding doxorubicin-resistant sublines were significantly reduced compared with paclitaxel dissolved in ethanol plus cremophor EL.
European journal of cancer  •  1994  |  View Paper
However, Taxol has some severe side effects related to Cremophor EL and ethanol.
Journal of nanomedicine & nanotechnology  •  2013  |  View Paper