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Last Updated: 3 years ago

Possible Interaction: Ethanol and Oxytocin





Research Papers that Mention the Interaction

Evidence continues to mount that OT administered either centrally, peripherally or intranasally can decrease ethanol intake in both humans and animal models.
Neuropharmacology  •  2020  |  View Paper
Further, there is some evidence to suggest that OXT may help to reverse neuroadaptations that occur as a result of chronic alcohol or drug exposure.
Brain Research  •  2020  |  View Paper
A considerable body of earlier animal studies demonstrated that oxytocin inhibits tolerance to alcohol , opioids, and stimulants as well as withdrawal from alcohol and opioids.
International review of neurobiology  •  2017  |  View Paper
Systemic administration of baclofen (2.5 mg/kg) or oxytocin (OXT; 10 mg/kg) reduced the EtOH intake in single housed control (baclofen, OXT) and CSC (baclofen) mice, whereas intracerebroventricular OXT (0.5 μg/2 μl) was ineffective in both groups.
Addiction biology  •  2013  |  View Paper
On the contrary, ethanol stimulates prolactin release from the adenohypophysis as well as oxytocin from the neurohypophysis.
Experimental Neurology  •  2010  |  View Paper
Tolerance to ethanol (e.g. hypothermia-inducing effect of ethanol) also was inhibited by OXT.
Psychoneuroendocrinology  •  1998  |  View Paper
Inhibition of contractions with ethanol is based on the capacity of alcohol to inhibit oxytocin secretion.
Wiener klinische Wochenschrift. Supplementum  •  1984  |  View Paper
Based on their shared capacity to enhance sociability, we hypothesized that both methamphetamine and alcohol would increase plasma oxytocin levels.
Journal of clinical psychopharmacology  •  2015  |  View Paper
BACKGROUND The neuropeptide, oxytocin (OT), has been reported to block tolerance formation to alcohol and decrease withdrawal symptoms in alcohol-dependent rodents.
Our results are consistent with previous findings in rodents that OT inhibits neuroadaptation to and withdrawal from alcohol.
Alcoholism, clinical and experimental research  •  2013  |  View Paper
ethanol levels in blood, decrease in … were significantly lower in the oxytocin than in the saline group (17.4 ± 3.8 vs 25.3 ± 4.2 mg/ml, 6.7 ± 1.… ± 0.9 mEq/L, and 0.49 ± 0.08 vs 0.66 ± 0.05 L, respectively; p <.05).
Journal of minimally invasive gynecology  •  2011  |  View Paper
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