Oxytocin treatment for alcoholism: Potential neurocircuitry targets

 administered either centrally, peripherally or intranasally can decrease 

 intake in both humans and animal models.

The role of oxytocin in alcohol and drug abuse

Further, there is some evidence to suggest that

 may help to reverse neuroadaptations that occur as a result of 

Oxytocin, Tolerance, and the Dark Side of Addiction.

A considerable body of earlier animal studies demonstrated that

, opioids, and stimulants as well as withdrawal from alcohol and opioids.

Differential effects of baclofen and oxytocin on the increased ethanol consumption following chronic psychosocial stress in mice

Systemic administration of baclofen (2.5 mg/kg) or

 intake in single housed control (baclofen, OXT) and CSC (baclofen) mice, whereas intracerebroventricular OXT (0.5 μg/2 μl) was ineffective in both groups.

Alcohol and endocannabinoids: Neuroendocrine interactions in the reproductive axis

 stimulates prolactin release from the adenohypophysis as well as 

OXYTOCIN AND ADDICTION: A REVIEW

 (e.g. hypothermia-inducing effect of ethanol) also was inhibited by 

[The importance of oxytocin and prostaglandins to the mechanism of labor in humans].

Inhibition of contractions with ethanol is based on the capacity of

Effects of Acute Doses of Prosocial Drugs Methamphetamine and Alcohol on Plasma Oxytocin Levels

Based on their shared capacity to enhance sociability, we hypothesized that both methamphetamine and

Intranasal oxytocin blocks alcohol withdrawal in human subjects.

 (OT), has been reported to block tolerance formation to 

 and decrease withdrawal symptoms in alcohol-dependent rodents.

Our results are consistent with previous findings in rodents that

 inhibits neuroadaptation to and withdrawal from 

An RCT: use of oxytocin drip during hysteroscopic endometrial resection and its effect on operative blood loss and glycine deficit.

 levels in blood, decrease in … were significantly lower in the 

 than in the saline group (17.4 ± 3.8 vs 25.3 ± 4.2 mg/ml, 6.7 ± 1.… ± 0.9 mEq/L, and 0.49 ± 0.08 vs 0.66 ± 0.05 L, respectively; p <.05).

Tocolysis, β2 agonists and anaesthesia

, which acts centrally by inhibiting the release of 

, was one of the first substances used, but is associated with a high incidence of headache, nausea and vomiting, and has never found favour in this country.

Inhibition by ethanol of the oxytocin response to breast stimulation in normal women and the role of endogenous opioids.

However, when ethanol was given together with naloxone, the

 rise induced by breast stimulation was only partially inhibited by 

 (the mean oxytocin peak was 50% higher than baseline).

The inhibitory effect of ethanol on oxytocin-induced labor at term.

 on the myometrium, although the possibility of some central inhibition of oxytocin release cannot be discounted.

Effect of different doses of ethanol on the milk-ejecting reflex in lactating women.

The study, thus, confirms earlier findings that

Inhibition of Oxytocin‐Induced Uterine Activity in Midpregnancy by Combined Adrenergic α‐Blockade and β‐Stimulation

Inhibition of uterine contractility in labor.

Abstract Uterine contractility was recorded by the direct electronic method in 4 groups of 12 women in labor, in order to … effect of: (1) pregnenolone sulfate, precursor of placental progesterone, expected to block the sensitivity of the myometrial cell; (2)

Effect of alcohol on threatened premature labor.

 during parturition and lactation in the rabbit and during lactation in the human.

 can inhibit the uterine activity during labor and that this presumably is due to an inhibition of the release of 

Oxytocin reverses ethanol consumption and neuroinflammation induced by social defeat in male mice

 administration blocked the increase in voluntary 

 consumption observed in defeated mice, although it did not affect motivation for ethanol.

Temporal analysis of individual ethanol consumption in socially housed mice and the effects of oxytocin

 intake on three out the four treatment days.

 treatments not only cause an acute decrease in 

 consumption, but can also change in efficacy over time.

Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala

 on GABA release in the CeA of dependent but not nondependent rats.

Oxytocin Reduces Ethanol Self‐Administration in Mice

 at doses that do not alter responding for a natural reward (sucrose).

 decreased responding and motivation (breakpoint values) for 

 at doses that did not alter responding for sucrose.

, 0.3, 1, 3, or 10 mg/kg) dose dependently reduced EtO

nsumption (maximal 45% reduction) in the binge drinking model, with lower effective doses having minimal effects on general locomotor activity.

Nucleus accumbens lentiviral-mediated gain of function of the oxytocin receptor regulates anxiety- and ethanol-related behaviors in adult mice

Studies using laboratory animals suggested an interaction between

These results provide further evidence that the

 system contributes to the regulation of 

 drinking and sensitivity and position OxtR as a central molecular mediator of ethanol's effects within the mesolimbic system.

Peripheral oxytocin administration reduces ethanol consumption in rats

For the three-bottle choice study, rats consumed significantly less

 when treated with the three higher doses of 

 gel consumption to a greater extent than plain gel consumption, both in terms of the amount of gel eaten and calories consumed.

Oxytocin prevents ethanol actions at δ subunit-containing GABAA receptors and attenuates ethanol-induced motor impairment in rats

The profound and direct interaction observed between

 at the behavioral and cellular level may have relevance for the development of novel therapeutics for alcohol intoxication and dependence.

Individual differences underlying susceptibility to addiction: Role for the endogenous oxytocin system

 system can influence effects of drugs and 

Recent research shows that the effects of oxytocin are more diverse than initially thought and that in some cases

 can directly influence the response to drugs and 

Simultaneous prenatal ethanol and nicotine exposure affect ethanol consumption, ethanol preference and oxytocin receptor binding in adolescent and adult rats.

Tolerance to acute ethanol inhibition of peptide hormone release in the isolated neurohypophysis.

) exposure reduces the evoked release of vasopressin (AVP) and oxytocin (

) from excised neurohypophyses and from dissociated neurohypophysial terminals of the rat.

Central inhibition of salt appetite by oxytocin in rats

injection of OT inhibits salt appetite stimulated by subcutaneous colloid; (b) treatments that inhibit NaCl intake, such as acute … secretion, such as systemic injection of deoxycorticosterone and dietary sodium deprivation, potentiate Ang-II-induced NaCl intake; (c) systemic

 secretion and enhances Ang-II-… by i.c.v.

Ethanol increases the activity of large conductance, Ca(2+)-activated K+ channels in isolated neurohypophysial terminals.

 inhibits the release of vasopressin and 

, we studied its effects on large conductance, Ca(2+)-activated K+ channels from these terminals using patch-clamp techniques.

Acute effects of ethanol on ingestive behavior in rats.

 pretreatment also significantly blunted pituitary secretion of 

 in response to multiple excitatory stimuli.

Low doses of ethanol may induce anti-nociceptive effects via an oxytocinergic mechanism.

In this study we wanted to investigate whether the antinociceptive effects of

Oxytocin attenuates tolerance not only to the hypothermic but also to the myorelaxant and akinesic effects of ethanol in mice

 has been demonstrated previously using the hypothermic effect only.

[Reactive characteristics of the neurohypophysis in the early postnatal period].

The maturity of the hypothalamic-neurohypophyseal system in the first 10 days of the postnatal life of rats was analysed through the potential inhibitory effect of

Intraventricular administration of neurohypophyseal hormones interferes with the development of tolerance to ethanol.

 or LVP (3 ng or 300 pg/animal) blocked the development of hypothermic tolerance to 

C-terminal fragments of oxytocin (prolyl-leucyl-glycinamide and Z-prolyl-D-leucine) attenuate the development of tolerance to ethanol.

) treatment inhibited the development of tolerance to 

The effects of neurohypophyseal hormones on tolerance to the hypothermic effect of ethanol.

The data suggest that both neurohypophyseal hormones (LVP and

) block the early developmental phase of tolerance to 

Effects of peptides related to neurohypophyseal hormones on ethanol tolerance

 attenuated the expression of tolerance but this may been due to an interaction with the acute effects of 

Effects of prostaglandin F 2 , oxytocin, and ethanol on the uterus of the pregnant baboon.

 at the threshold level of 4 mU. per minute was diminished by 

 but ethanol did not diminish uterine response to the higher doses of 8 and 15 mU. of oxytocin per minute.

Milk Ejection during Alcohol Anaesthesia in the Rat

 during labour and milk ejection has received wide acceptance and studies purporting to show this inhibitory function have been conducted on the rabbit1, woman2 and the rat3.

Oxytocin-induced stretch reaction in suckling mice and rats: a semiquantitative bio-assay for oxytocin.

Pups suckling on lactating mice or rats which have been anesthetized with

 show a unique reaction after the intravenous or intra-arterial injection of 

Oxytocin signaling in the treatment of drug addiction: Therapeutic opportunities and challenges.

More importantly, clinical studies have also shown that

 can exert beneficial effects on reducing substance use disorders of a series of drugs, such as heroin, cocaine, 

Endogenous Opioids Modulate the Oxytocin Response to Insulin‐Induced Hypoglycaemia and Partially Mediate the Inhibitory Effect of Ethanol in Man

) response to insulin‐induced hypoglycaemia was tested in man.

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Possible Interaction: Ethanol and Oxytocin

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Research Papers that Mention the Interaction