Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Ethanol and Oxycodone



Research Papers that Mention the Interaction

Conclusions: Ethanol together with oxycodone causes greater ventilatory depression than either alone, the magnitude of which is clinically relevant.
Ethanol caused a further decrease of oxycodone-induced respiratory depression by another 19% at 1 g/l ethanol plus oxycodone (P < 0.01 vs. oxycodone).
Ethanol combined with oxycodone caused a significant increase in the number of apneic events measured in a 6-min window with a median (range) increase from 1 (0 to 3) at 0 g/l ethanol to 1 (0 to 11) at 1 g/l ethanol (P < 0.01).
Mean (95% CI) VE55 decreased from 33.4 (27.9 to 39.0) l/min (control) to 18.6 (15.6 ….6) l/min (oxycodone, P < 0.01 vs. control) and to 15.7 (12.7 to 18.6) l/min oxycodone … ethanol , 1 g/l; ….01 vs. oxycodone).
Anesthesiology  •  2017  |  View Paper
Absorption of ethanol was decreased by oxycodone.
ConclusionsIn this study, 10 mg of oral oxycodone combined with a low dose of ethanol generated abuse liability-related effects, but when tested separately, they did not.
Psychopharmacology  •  2011  |  View Paper
Deaths attributable to oxycodone are usually associated with polysubstance abuse in which oxycodone is combined with psychostimulants, other opioids, benzodiazepines or alcohol.
Supportive Care in Cancer  •  2002  |  View Paper
Oxycodone tolerance was reversed in isolated DRG neurons by the acute application of either ethanol (20 mM) or the PKC inhibitor, bisindolylmaleimide XI hydrochloride (Bis XI), when a challenge of 3 µM oxycodone significantly reduced neuronal excitability following prolonged exposure.
Molecular Pharmacology  •  2018  |  View Paper
It took twice as much ethanol , when given orally, to reverse the tolerance to oxycodone.
Oral ethanol (2 g/kg) reversed the tolerance to chronic oxycodone , but did not alter brain concentrations of either acute or chronic oxycodone.
The Journal of Pharmacology and Experimental Therapeutics  •  2017  |  View Paper