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Last Updated: a year ago

Possible Interaction: Ethanol and Oxazepam

supplement:

Ethanol

Research Papers that Mention the Interaction

In addition to a sedative effect the interaction of alcohol and oxazepam in the oxazepam trial results in dysphoric changes of mood and related significant alterations of polarity profiles.
International journal of clinical pharmacology and biopharmacy  •  1977  |  View Paper
Pretreatment of rats with ethyl alcohol increased significantly the concentration of the hydroxylated metabolite, free oxazepam , in the plasma, but not of the demethylated metabolite, N-demethyldiazepam.
Acta pharmacologica et toxicologica  •  1975  |  View Paper
The concomitant influence of ethanol and oxazepam accentuates the motoric instability with a delay of the motoric responses.
The results indicate the existence of marked interactions between ethanol and oxazepam.
International journal of clinical pharmacology and biopharmacy  •  1976  |  View Paper
Ethanol pretreatment resulted in rapid cross-tolerance, on both tests, to the various alcohols (n-propanol, n-butanol, and t-butanol) and the benzodiazepines (chlordiazepoxide, diazepam, oxazepam , and flurazepam) tested.
Pharmacology Biochemistry and Behavior  •  1992  |  View Paper
Ethanol reduced oxazepam levels but increased desmethyl diazepam levels, suggesting that 3‐hydroxylation of desmethyl diazepam was inhibited by ethanol.
British journal of pharmacology  •  1977  |  View Paper