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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Oseltamivir
Research Papers that Mention the Interaction
“ Alcohol increased the oseltamivir area under the plasma concentration–time curve (AUC) from 0 to 6 h (AUC0 → 6 h) by 27 % (range 11–46 %, p = 0.011) and decreased the metabolite/oseltamivir AUC0 → 6 h ratio by 34 % (range 25–41 %, p < 0.001).”
Effects of Alcohol on Human Carboxylesterase Drug Metabolism“The observed exposures to oseltamivir were increased by 46 and 37 % for the area under the plasma concentration–time curve from time zero to 6 h (AUC6) and from time zero to 24 h (AUC24), respectively, with co-administration of ethanol 0.6 g/kg.”
“Indeed, there are numerous commonly prescribed drugs with significant carboxylesterase-mediated metabolism such as enalapril, lovastatin, irinotecan, clopidogrel, prasugrel, methylphenidate, meperidine, and oseltamivir that may interact with ethanol.”
The Effect of Ethanol on Oral Cocaine Pharmacokinetics Reveals an Unrecognized Class of Ethanol-Mediated Drug Interactions“ Oseltamivir is known to alter neuronal function and behavior in animals, particularly when administered in combination with ethanol.”
“ Ethanol injection in the presence of oseltamivir also resulted in enhanced hypothermia.”
“However, prior injection of oseltamivir significantly altered the duration of loss of lightning reflex following ethanol injection (3.3g/kg, i.p.).”
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