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Last Updated: 2 years ago

Possible Interaction: Ethanol and Oseltamivir

supplement:

Ethanol

Research Papers that Mention the Interaction

Alcohol increased the oseltamivir area under the plasma concentration–time curve (AUC) from 0 to 6 h (AUC0 → 6 h) by 27 % (range 11–46 %, p = 0.011) and decreased the metabolite/oseltamivir AUC0 → 6 h ratio by 34 % (range 25–41 %, p < 0.001).
Clinical Pharmacokinetics  •  2014  |  View Paper
The observed exposures to oseltamivir were increased by 46 and 37 % for the area under the plasma concentration–time curve from time zero to 6 h (AUC6) and from time zero to 24 h (AUC24), respectively, with co-administration of ethanol 0.6 g/kg.
Clinical Pharmacokinetics  •  2014  |  View Paper
Indeed, there are numerous commonly prescribed drugs with significant carboxylesterase-mediated metabolism such as enalapril, lovastatin, irinotecan, clopidogrel, prasugrel, methylphenidate, meperidine, and oseltamivir that may interact with ethanol.
Drug Metabolism and Disposition  •  2010  |  View Paper
Oseltamivir is known to alter neuronal function and behavior in animals, particularly when administered in combination with ethanol.
Human & experimental toxicology  •  2008  |  View Paper
Ethanol injection in the presence of oseltamivir also resulted in enhanced hypothermia.
However, prior injection of oseltamivir significantly altered the duration of loss of lightning reflex following ethanol injection (3.3g/kg, i.p.).
Neuroscience Letters  •  2007  |  View Paper