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Last Updated: 2 years ago

Possible Interaction: Ethanol and Ondansetron

supplement:

Ethanol

Research Papers that Mention the Interaction

Pretreatment with ondansetron significantly attenuated several of the subjective pleasurable effects of alcohol , and also decreased the subjective desire to drink.
Psychopharmacology  •  2005  |  View Paper
In a recent study (Johnson et al. 1993) we found that a single oral dose of the 5-HT3 receptor antagonist ondansetron (4 mg) in healthy male volunteers attenuated some of the pleasurable effects of a tow dose of alcohol (580 ml lager).
There is, for example, some evidence that ondansetron might inhibit gut motility (Talley et al. 1990); thus, it is conceivable that ondansetron might have impaired the absorpt ion of alcohol into the bloodstream.
While this effect is consistent with data f rom animal studies suggesting that 5-HT3 receptor blockade can diminish the reinforcing properties of drugs … in the nucleus accumbens (Carboni et al. 1989; Wozniak et al. 1990; Yoshimoto et al. 1992), we could not exclude the possibility that ondansetron … alcohol.
Psychopharmacology  •  2005  |  View Paper
Ondansetron was found to augment certain stimulant, sedative, and discriminant effects of alcohol , without affecting psychomotor performance or alcohol pharmacokinetics.
Biological Psychiatry  •  1996  |  View Paper
The solubility of ondansetron also increased as the ethanol concentration increased.
The Journal of pharmacy and pharmacology  •  2001  |  View Paper
Benzodiazepines, clomethiazole, tiagabine, vigabatrin, pregabalin, gabapentin, acamprosate, naltrexone, GHB, topiramate, ondansetron and baclofen at low dose (≤1 mg/kg, the dose range used in randomized trials in humans: 30 and 60 mg/day) have all been shown to at best reduce motivation to consume alcohol in rats.
Journal of psychopharmacology  •  2012  |  View Paper
Considering these antecedents, we explored modulation of the acute stimulating effect of ethanol (2.5g/kg) by two anxiolytic drugs, Mianserin (2.5 or 5mg/kg) and Ondansetron (1 or 3mg/kg).
Pharmacology Biochemistry and Behavior  •  2011  |  View Paper
In addition, ondansetron (1.0 mg/kg, subcutaneously) given before ethanol injection on days 1, 4, 7, and 10 significantly blocked the development (days 1, 4, 7, and 10), and expression (day 15) of sensitization to the locomotor stimulant effect of ethanol injection.
Results indicated that ondansetron (0.25–1.0 mg/kg, subcutaneously) given before the challenge dose of ethanol (2.4 g/kg, intraperitoneally) injection, significantly and dose dependently attenuated the expression of sensitization.
Behavioural pharmacology  •  2009  |  View Paper
Acute administration of ondansetron (0.01 and 0.1 mg/kg) reduced ethanol intake in male Wistar rats by 35%, whilst water intake was unaffected.
Psychopharmacology  •  2005  |  View Paper
The effect of 2.0 g/kg of EtOH was reduced by ON (0.1 mg/kg and 1.0 mg/kg sc) and, to the lesser extent and only in limited dose range (0.01 mg/kg) by TR.
Tropisetron (but not ON ) increased concentrations of EtOH in the blood.
Polish journal of pharmacology  •  1995  |  View Paper
Ondansetron also modulates the toxicities of ethanol in the stomach and this action is likely to be mediated through the preservation of GMBF.
Pharmacology  •  1994  |  View Paper
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