Possible Interaction: Ethanol and Oleic Acid

“Fatty acid profiling demonstrated that alcohol feeding dramatically increased hepatic unsaturated long chain fatty acyl species, particularly linoleic acid and oleic acid , which was attenuated by dietary MCT.”

“The … alcohol to rat and human liver slices depressed the formation … 14 CO 2 from palmitic acid-1- 14 C, oleic acid-1- 14 C and linoleic acid-1- 14 C. The esterification to triglycerides … phospholipids was increased and the formation of β-keto acids was decreased by alcohol.”

“In WIF-B cells treated with ethanol and/or oleic acid (a fatty acid associated with the "Western" diet), we found that ethanol dramatically increased lipid droplet numbers and led to the formation of large, peripherally-located droplets.”

“Conversion of [1-14C] palmitic to oleic acid and eicosatrienoic to arachidonic acid were inhibited in 400 mM ethanol treated cells suggesting an inhibition of delta 9 and delta 5 desaturase activity.”

“In the optimized formula, the presence of ethanol and PEG 400 disrupts SC lipids exhibiting rapid ex vivo release profile compared to other NEs and to ATOR in OA.”

“For meconium of the ethanol offspring (n=25 fetuses) compared with the sucrose offspring (n=23 fetuses), the total FAEE concentration was 8-fold higher; and lauric, palmitic, stearic and oleic AEE concentrations were at least 5-fold higher for the ethanol group.”

“We tested the hypothesis in unanesthetized lymph-fistula rats that ethanol might also enhance the mucosal absorption and lymphatic transport of oleic acid when oleate absorption rates were low.”

“ Ethanol administration for a period of 60 days modifies the fatty acid composition, and the analysis of … significant increase in the concentrations of palmitic acid (16:0), stearic acid (18:0), and oleic acid (18:1) in liver, kidney, and brain, whereas … arachidonic acid (20:4) were significantly decreased.”

“We also showed that the most ethanol-tolerant transformant, which expresses the insect desaturase TniNPVE, produces twice as much … acid as palmitoleic acid in the absence of ethanol and undergoes a fourfold increase in the ratio of oleic acid to palmitoleic acid in response to exposure to 5% ethanol.”

“In the 1st and 2nd generations the percentage of stearic acid (18:0) decreased and palmitoleic (16:ln7) and oleic acid (18:ln9) increased in both adipose tissues of ethanol‐treated rats with respect to control.”