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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Ethanol
drug:
Nordazepam
Research Papers that Mention the Interaction
“Pretreatment of rats with ethyl alcohol increased significantly the concentration of the hydroxylated metabolite, free oxazepam, in the plasma, but not of the demethylated metabolite, N-demethyldiazepam.”
Human and animal study on elimination from plasma and metabolism of diazepam after chronic alcohol intake.“This metabolization pattern is apparently the result of the inhibitory effect of ethanol on hydroxylization processes during biotransformation of the metabolite nordiazepam.”
“Ethanol reduced oxazepam levels but increased desmethyl diazepam levels, suggesting that 3‐hydroxylation of desmethyl diazepam was inhibited by ethanol.”
METABOLIC BASIS FOR THE SUPRA‐ADDITIVE EFFECT OF THE ETHANOL‐DIAZEPAM COMBINATION IN MICE
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