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Last Updated: 7 months ago

Possible Interaction: Ethanol and Nordazepam

supplement:

Ethanol

Research Papers that Mention the Interaction

Pretreatment of rats with ethyl alcohol increased significantly the concentration of the hydroxylated metabolite, free oxazepam, in the plasma, but not of the demethylated metabolite, N-demethyldiazepam.
Acta pharmacologica et toxicologica  •  1975  |  View Paper
This metabolization pattern is apparently the result of the inhibitory effect of ethanol on hydroxylization processes during biotransformation of the metabolite nordiazepam.
Arzneimittel-Forschung  •  1978  |  View Paper
Ethanol reduced oxazepam levels but increased desmethyl diazepam levels, suggesting that 3‐hydroxylation of desmethyl diazepam was inhibited by ethanol.
British journal of pharmacology  •  1977  |  View Paper