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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Nomifensine
Research Papers that Mention the Interaction
“We have observed that chronic daily exposure to a relatively high dose of alcohol can induce depressive-like behavior in rats and that pretreatment with nomifensine or imipramine can block the "depressogenic" effects of alcohol.”
Alcohol induced depressive-like behavior is associated with a reduction in hippocampal BDNF“Neonatal exposure to nomifensine increased voluntary intake of 10% (v/v) alcohol when the rats were 2–3 months of age.”
“Treatment with nomifensine potentiated electrically or high potassium concentration-evoked [(3)H]dopamine release, but inhibited the effects of ethanol on [(3)H]dopamine release from the nucleus accumbens slices.”
“The potency of nomifensine as a reinforcer was significantly increased by 1000 mg/kg ethanol , but again, this enhancement was limited to the same two subjects.”
“contrarily, NOM decreased the duration of ethanol narcosis, potentiated PCPA and antagonized the influence of AMPT.”
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