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Last Updated: 7 months ago

Possible Interaction: Ethanol and Nizatidine

supplement:

Ethanol

Research Papers that Mention the Interaction

We refer to studies, primarily by Lieber and colleagues, indicating that therapeutic doses of cimetidine, ranitidine, and nizatidine , but not famotidine, elevate blood ethanol levels in nonalcoholic men following ingestion of moderate amounts of alcohol (approximately one or two glasses of wine or cans of beer) [2-4].
Annals of Internal Medicine  •  1993  |  View Paper
Both ranitidine and nizatidine enhanced the absorption of small doses of alcohol (0.15 g/kg) in the morning by 63% and 64% and increased Cmax by 48% and 54% respectively (p less than 0.001), effects similar to those reported by others for cimetidine.
The American journal of gastroenterology  •  1991  |  View Paper
It is concluded that some H2-receptor antagonists (cimetidine and nizatidine , in particular) can inhibit gastric ethanol oxidation and thus increase blood alcohol levels after drinking.
Clinical therapeutics  •  1991  |  View Paper
Expert opinion: At doses of 0.15–0.30 mg/kg in the postprandial state (primarily after breakfast), the H2-receptor antagonists: cimetidine, ranitidine, famotidine, and nizatidine have all been found to increase the first-pass metabolism of ethanol.
Expert opinion on drug safety  •  2018  |  View Paper