Possible Interaction: Ethanol and Nitroprusside

“When ethanol was added to the perfusate to monitor blood flow, the escape of alcohol from the dialysate was accelerated by 30% with hydralazine or nitroprusside (P < 0.01) and 30% retarded (P < 0.05) by clonidine (10(-10) mol/liter).”

“Vascular responsiveness to the depressor agent SNP was enhanced during chronic ethanol intake.”

“Conversely, 8-bromo-cGMP and sodium nitroprusside blocked the increased exploration of open arms exhibited by rats treated with a higher dose of ethanol (1.2g/kg).”

“ Ethanol acts at this step, because it completely blocked the release of PGE2, leukotrienes, and LHRH induced by NP.”

“ Ethanol acts at this step since it completely blocks the release of LHRH induced by NP and the increase in PGE2 induced by NP.”

“The reinforcing properties of ethanol and morphine were reduced by sodium nitroprusside at a dose equal to 1/10 of LD50 given before preference testing.”

“ Ethanol completely blocked the release of LHRH induced by NP and the increase in PGE2 induced by NP.”

“3 Relaxations induced by sodium nitroprusside (SNP, 10 nm) were inhibited by ethanol (20–500 mm) in a concentration‐dependent manner and by propan‐2‐ol (100 mm).”

“ Ethanol at the physiologically relevant concentration of 4.0 mg/mL or more significantly decreased basal guanylate cyclase activity and inhibited activation of the enzyme by sodium nitroprusside (SNP) in cultured porcine coronary smooth muscle cells.”

“Intact cell study revealed that although 12.0 mg/mL or more ethanol was needed to significantly decrease cyclic GMP accumulation in control cells, 4.0 mg/mL or more ethanol significantly inhibited the increase of cyclic GMP accumulation induced by 1 μm SNP.”

“Because ethanol inhibits physiologic responses to excitatory amino acids, we examined its effect on toxicity induced by N‐methyl‐D‐aspartate and by the nitric oxide donor sodium nitroprusside in neuron‐enriched cultures prepared from rat cerebral cortex.”