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Last Updated: 2 years ago

Possible Interaction: Ethanol and Nitroarginine

supplement:

Ethanol

Research Papers that Mention the Interaction

Cerebellar surface application of nitric oxide synthesis (NOS) inhibitor, L-NNA (5 mM) significantly decreased the amplitude of P1 and the pause of SS firing in EtOH exposure group, but did no effect on control group.
Neuroscience Letters  •  2020  |  View Paper
The NO donors and L-arginine applied as pretreatment prior to ethanol resulted in diminishing of its damaging action that was similar for all these drugs, while L-NNA intensified both the injury and the drop in the PD values caused by ethanol.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  2001  |  View Paper
It is possible that this effect is not caused by the interaction of ethanol with nitric oxide pathways but by synergistic CNS depression caused by ethanol and L-NOARG.
L-NOARG at doses of 20 and 40 mg/kg reduced the exploratory activity of rats in the open-field test and significantly enhanced the sedative effect of ethanol in this test.
Moreover, the combined administration of ethanol (2 g/kg) and L-NOARG (20 and 40 mg/kg) caused a decrease in the body weight of animals, observed for 14 days.
European Neuropsychopharmacology  •  2000  |  View Paper
L-NOARG also significantly increased the toxicity of ethanol as evidenced by increased post-experimental lethality.
Alcohol and alcoholism  •  1998  |  View Paper
Moreover, the nitric oxide synthase inhibitor L-nitroarginine blocks tolerance to the effects of ethanol.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas  •  1996  |  View Paper
Pretreatment with L-NNA decreased both mucosal blood flow and ISO2 in the basal period and enhanced decreases in both mucosal blood flow (2.7-fold) and ISO2 (4.3-fold) induced by 30% ethanol compared with controls.
RESULTS Pretreatment with L- NA si gnificantly increased macroscopic (7.7-fold) and microscopic damage caused by 30% eth anol.
Gastroenterology  •  1995  |  View Paper
The first demonstrated that L-NA prevented the development of rapid tolerance to ethanol when injected prior to ethanol either on both Days 1 and 2 or only on Day 1.
We recently reported that the nitric oxide (NO) synthase inhibitor L-nitroarginine (L-NA) blocks the development of rapid tolerance to the motor incoordinating effect of ethanol in the tilt-plane test.
Brain Research Bulletin  •  1995  |  View Paper
Ethanol also inhibited the acetylcholine-induced relaxation resistant to nitro-L-arginine.
European journal of pharmacology  •  1993  |  View Paper
However, ethanol attenuated the reflex HR responses of NG-nitro-L-arginine and angiotensin II but not that of noradrenaline.
The results demonstrate that ethanol selectively but non-competitively inhibits the MAP response to NG-nitro-L-arginine , suggesting an interaction between ethanol and the L-arginine/nitric oxide pathway.
infusions of ethanol dose dependently reduced maximum MAP response to NG-nitro-L-arginine , with a Ki of 96 +/- 8 mg/kg per min but did not alter the ED50.
European journal of pharmacology  •  1993  |  View Paper
The cardiovascular effects of EtOH were significantly attenuated by ICV or by RVLM post treatment with ketamine (an NMDA receptor antagonist), N5-(nitroamidino)-L-2,5-diaminopentanoic acid ( L-NNA ; a NO synthase inhibitor), or bicuculline (a GABA receptor antagonist).
Alcoholism, clinical and experimental research  •  2018  |  View Paper