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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“ Alcohol is a commonly used recreational substance with complex vascular effects, which may, in part, be mediated by nitric oxide.”
No adverse hemodynamic interaction between sildenafil and red wine“In conclusion, ethanol decreases levels of nitric oxide in exhaled air in humans, likely by inhibition of airway formation of nitric oxide.”
“Thus, peak values for nitric oxide in exhaled air, in the first exhalation after breath-holding for 30 s, decreased to 56 +/- 10 and 37 +/- 12% of control 60 min after ingestion of ethanol at 0.25 and 1 g kg-1, respectively.”
“ Nitric oxide exerts its protective effects against alcohol via a specific signaling pathway, the NO–cGMP–PKG pathway.”
“Furthermore, alcohol feeding lowered the activities of NADH dehydrogenase, succinate dehydrogenase (SDH), and cytochrome c oxidase and the content of cytochromes followed by increased levels of nitric oxide ( NO ), thiobarbituric acid-reactive substances, and protein carbonyls.”
“In the cell model of microglia stimulated by herpes simplex virus (HSV), with the ethanol extract intervention, TNF-α, IL-1β and NO levels were significantly decreased and cell death of BV-2 cells were markedly increased.”
“Furthermore, NO is involved in EtOH induced liver damage and has a role in fetal development during EtOH exposure in pregnancy.”
“ NO also inhibits EtOH metabolizing enzymes.”
“On the other hand, it is clear that acute low doses of EtOH increase both the release of NO and endothelial NOS (eNOS) expression, and augment endothelium-mediated vasodilatation, whereas higher doses impair endothelial functions.”
“Therefore, there is an excellent chance for EtOH and NO to react with each other.”
“ Alcohol increased plasma NO (measured with chemiluminescence) by 63%.”
“ Ethanol administration induces an increase in vasoactive agents such as endothelin and nitric oxide and oxidative stress.”
“ Ethanol induced a significant increase in both basal and stimulated NO production as determined by chemiluminescence method.”
“These results demonstrate that ethanol augments both basal and stimulated NO production and that this effect is associated with increased eNOS protein and mRNA expression levels.”
“In addition, ethanol stimulated neutrophil NO generation.”
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