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Possible Interaction: Ethanol and Nitric Oxide



Research Papers that Mention the Interaction

Alcohol is a commonly used recreational substance with complex vascular effects, which may, in part, be mediated by nitric oxide.
Clinical pharmacology and therapeutics  •  2004  |  View Paper
In conclusion, ethanol decreases levels of nitric oxide in exhaled air in humans, likely by inhibition of airway formation of nitric oxide.
Thus, peak values for nitric oxide in exhaled air, in the first exhalation after breath-holding for 30 s, decreased to 56 +/- 10 and 37 +/- 12% of control 60 min after ingestion of ethanol at 0.25 and 1 g kg-1, respectively.
European journal of pharmacology  •  1994  |  View Paper
Nitric oxide exerts its protective effects against alcohol via a specific signaling pathway, the NO–cGMP–PKG pathway.
Cellular and Molecular Neurobiology  •  2015  |  View Paper
Furthermore, alcohol feeding lowered the activities of NADH dehydrogenase, succinate dehydrogenase (SDH), and cytochrome c oxidase and the content of cytochromes followed by increased levels of nitric oxide ( NO ), thiobarbituric acid-reactive substances, and protein carbonyls.
Journal of medicinal food  •  2011  |  View Paper
In the cell model of microglia stimulated by herpes simplex virus (HSV), with the ethanol extract intervention, TNF-α, IL-1β and NO levels were significantly decreased and cell death of BV-2 cells were markedly increased.
International journal of immunopathology and pharmacology  •  2011  |  View Paper
Furthermore, NO is involved in EtOH induced liver damage and has a role in fetal development during EtOH exposure in pregnancy.
NO also inhibits EtOH metabolizing enzymes.
On the other hand, it is clear that acute low doses of EtOH increase both the release of NO and endothelial NOS (eNOS) expression, and augment endothelium-mediated vasodilatation, whereas higher doses impair endothelial functions.
Therefore, there is an excellent chance for EtOH and NO to react with each other.
Current clinical pharmacology  •  2007  |  View Paper
Alcohol increased plasma NO (measured with chemiluminescence) by 63%.
Life sciences  •  2002  |  View Paper
Ethanol administration induces an increase in vasoactive agents such as endothelin and nitric oxide and oxidative stress.
Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence  •  2001  |  View Paper
Ethanol induced a significant increase in both basal and stimulated NO production as determined by chemiluminescence method.
These results demonstrate that ethanol augments both basal and stimulated NO production and that this effect is associated with increased eNOS protein and mRNA expression levels.
Thrombosis and haemostasis  •  1999  |  View Paper
In addition, ethanol stimulated neutrophil NO generation.
Journal of leukocyte biology  •  1999  |  View Paper
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