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Possible Interaction: Ethanol and Nitrendipine

supplement:

Ethanol

Research Papers that Mention the Interaction

Dihydropyridine calcium channel antagonists, such as nitrendipine , have been previously found to prevent some of the adaptive responses to chronic ethanol intake.
However, the potentiation after in vivo administration of ethanol plus nitrendipine was significantly greater than after ethanol alone.
When LTP was produced by a transient increase in the calcium concentration in the bathing medium, the chronic ethanol treatment did not alter the potentiation of the population spike height, but in vivo treatment with ethanol plus nitrendipine decreased the potentiation.
Experimental Brain Research  •  2004  |  View Paper
Repeated administration of nitrendipine blocked the antinociceptive effects of chronic ethanol and prevented the hyperalgesia produced by ethanol withdrawal.
The highest dose of nitrendipine (10 mg/kg, twice daily) reduced consumption of the ethanol diet.
Alcoholism, clinical and experimental research  •  2002  |  View Paper
In the third series … ICV injection of nitrendipine in doses of 0.024, 0.16, … mg incorporated in the solution of ethanol , given in volumes of 0.03, 0.2, and 0.3 mt, respectively, blocked … the convulsions induced by the 1.0 mg dose of nicotine given ICV.
Alcohol  •  1999  |  View Paper
In the locomotor studies, both felodipine and nitrendipine significantly decreased the locomotor stimulation produced by ethanol ; the effects of the two compounds were similar, but dose-dependency was not seen at the doses tested.
Brain Research Bulletin  •  1998  |  View Paper
The increases in handling-induced behavior … in mice during withdrawal from chronic ethanol treatment were prevented … administration of nitrendipine , 50 mg/kg, but not by, felodipine, 10 mg/kg, a dose that caused a similar displacement of dihydropyridine binding in central nervous system tissue, in vivo and in vitro.
Withdrawal from the ethanol chronic treatment increased the thresholds to seizures produced by intravenous aminophylline; this change was also prevented by nitrendipine.
Alcoholism, clinical and experimental research  •  1997  |  View Paper
It is known that co-administration of dihydropyridine derivative nitrendipine suppresses the development of physical dependence on ethanol.
The Journal of toxicological sciences  •  1995  |  View Paper
The density of cerebral cortical A1-adenosine receptors and of nitrendipine binding sites on calcium channels were significantly increased after chronic ethanol , while the density of striatal A2a-adenosine receptors were unchanged.
Brain Research  •  1994  |  View Paper
4 Nitrendipine (50 mg kg−1) prevented the behavioural signs of ethanol withdrawal as measured by handling induced convulsions, but felodipine (10 mg kg−1 or 2 mg kg−1) did not provide any protection against this effect of ethanol withdrawal.
Suggested explanations for the results include the possibility that nitrendipine may protect against the ethanol withdrawal syndrome via sites other than dihydropyridine receptors: that felodipine has partial agonist actions at dihydropyridine receptors in the CNS or that felodipine has actions which mask its protective effect in ethanol withdrawal.
British journal of pharmacology  •  1994  |  View Paper
Nitrendipine (25-100 mg/kg) was unable to reverse the anxiogenic responses detected on withdrawal from ethanol , but the highest dose did reduce withdrawal tremor.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  1992  |  View Paper
1 Chronic treatment with the dihydropyridine calcium channel antagonist, nitrendipine , given concurrently with ethanol , prevented the ethanol withdrawal syndrome in mice, even though the chronic nitrendipine treatment was stopped 24 h or 48 h before the withdrawal testing.
British journal of pharmacology  •  1991  |  View Paper
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