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“In combination with a noneffective oral dose (1 g/kg) of ethanol , the reductions in both total duration and peak frequency of RSA caused by nitrazepam , unlike those by Ro 41-3696 and zopiclone, were significantly potentiated.”
“Brotizolam, nitrazepam and estazolam enhanced the sleeping time induced by ethanol and increased locomotor activity induced by methamphetamine, but did not affect the chewing behavior.”
“When nitrazepam was used as the substrate (1 mM) for the isolated perfused rat liver, addition of ethanol (38 mM) led to an enhanced content of 7-amino derivative in the liver and in the perfusate, whereas the formation of 7-acetylamino derivative remained unchanged.”