Possible Interaction: Ethanol and Ng-Nitroarginine Methyl Ester

“ Ethanol at a dose of 0.4 g/kg of body weight per day decreased ACE activity in the aorta of aged rats and of rats treated with L-NAME or dexamethasone to the level of activity in young control rats.”

“Whereas, co-administration … of NMDAR, and NG-nitro-L-arginine methyl ester (L-NAME, 10 mg/kg), 7-nitroindazole (7-NI, 30 mg/kg), methylene blue (10 mg/kg) as … (ODQ) (20 mg/kg) a nitric oxide/cyclic-guanosine monophosphate (NO-cGMP) inhibitor, with a subeffective dose of ethanol (….”

“In cultured aortic vascular smooth muscle cells (VSMCs), ethanol stimulated generation of NO, which was significantly inhibited by l-NAME.”

“Pre-test co-administration of a higher dose of l-NAME (1 microg/mouse, intra-CA1) with an ineffective dose of ETOH (0.25 g/kg), improved the memory retrieval.”

“Results: After 2 weeks of treatment with ethanol and L-NAME , blood urea and creatinine levels were significantly increased.”

“… N‐nitro‐l‐arginine methyl ester ) (100 μmol L−1), AG (aminoguanidine) (10 μmol L−1), ODQ (1H‐[1,2,4]Oxadiazolo[4,3‐a]quinoxalin‐1‐… (2‐Phenyl‐4,4,5,5‐tetramethylimidazoline‐1‐oxyl 3‐oxide) (200 μmol L−1) partly blocked the inhibitory effect of ethanol ….”

“In ovariectomized and SHAM rats, administration of L-NAME together with ethanol , produced a significant increase in IL-1beta, IL-6 and TNFalpha levels.”

“ L-NAME , BRM, QPR and 7-OH-DPAT blocked the ethanol (0.5 g/kg)-induced locomotor hyperactivity dose dependently and at doses that did not affect locomotor activity in naive mice when administered alone.”

“The nonspecific NO blocker NG-nitro-l-arginine-methyl-esther , but not the inactive isomer N-nitro-d-arginine-methyl-esther (d-NAME), inhibited ethanol inhibitory actions on beta-EP release.”

“However, in the presence of L-NAME, ethanol reduced k(s) in jejunal mucosal and seromuscular layers by -35% (P <.01) and -30% (P <.01), respectively, compared with controls.”