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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Nerve Growth Factor
Research Papers that Mention the Interaction
“Results NGF and BDNF changes play a subtle role in short- and long-lasting effects of alcohol in ethanol target tissues, including neuronal cell death and severe cognitive and physiological deficits in the newborns.”
NGF and BDNF Alterations by Prenatal Alcohol Exposure“BACKGROUND Recent studies have raised the possibility that nerve growth factor NGF ) is abnormally regulated in the central nervous system (CNS) of animal models of chronic ethanol treatment.”
“Thus, we tested the hypothesis that exposure to ethanol would affect NGF synthesis as well as expression of NGF receptor trkA in this cell population.”
“The adverse effects of ethanol on Mt function were reduced by pretreating the cells with broad-spectrum caspase inhibitors and nearly abolished by nerve growth factor stimulation , with or without concomitant treatment with global caspase inhibitors.”
“ NGF markedly increased LC3-II production after treatment with alcohol in a dose-dependent manner.”
Nerve Growth Factor Protects Against Alcohol-Induced Neurotoxicity in PC12 Cells via PI3K/Akt/mTOR Pathway“We found that exposure to ethanol resulted in elevated levels of nerve growth factor (NGF) and TrkA mRNA expression but a decreased level of brain-derived neurotrophic factor (BDNF) mRNA expression.”
“In the fetal CP, NGF did not affect the incidence of cell death, but ethanol increased it.”
“Thus, NGF can be protective against the neurotoxic effect of ethanol in the neonatal brain.”
“The result of our study indicates that NGF synthesis and the functional activity of NGF-target cells localized in the brain are markedly influenced by ethanol intake.”
“6-month alcohol treatment led to an increase of NGF to 650–850% of controls in the basal forebrain and the septum and to a 210–485% increase in the cholinergic projection areas (anterior cortex, hippocampus and olfactory bulb).”
“After 9 months exposure to ethanol , a decrease of NGF by 16% in the frontal cortex was observed compared to controls.”
“Estrogen, bFGF, and NGF increased total neurite length after ethanol treatment.”
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