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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Ethanol and Nelfinavir



Research Papers that Mention the Interaction

Although ethanol did not alter k(cat), it decreased the K(m) of nelfinavir , suggesting a decrease in catalytic efficiency (k(cat)/K(m)).
Ethanol (20mM) decreased the K(D) of nelfinavir by >5-fold (0.041±0.007 vs. 0.227±0.038μM).
Similarly, 20mM ethanol decreased the IC(50) of nelfinavir by >3-fold (2.6±0.5 vs. 8.3±3.1μM).
These results suggest that ethanol facilitates binding of nelfinavir with CYP3A4.
Biochemical and biophysical research communications  •  2010  |  View Paper