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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Nelfinavir
Research Papers that Mention the Interaction
“Although ethanol did not alter k(cat), it decreased the K(m) of nelfinavir , suggesting a decrease in catalytic efficiency (k(cat)/K(m)).”
“ Ethanol (20mM) decreased the K(D) of nelfinavir by >5-fold (0.041±0.007 vs. 0.227±0.038μM).”
“Similarly, 20mM ethanol decreased the IC(50) of nelfinavir by >3-fold (2.6±0.5 vs. 8.3±3.1μM).”
“These results suggest that ethanol facilitates binding of nelfinavir with CYP3A4.”
Effect of ethanol on spectral binding, inhibition, and activity of CYP3A4 with an antiretroviral drug nelfinavir.
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