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Possible Interaction: Ethanol and Naltrexone

supplement:

Ethanol

Research Papers that Mention the Interaction

Treatment with the μ-opiate receptor antagonist naltrexone has been shown to reduce craving for alcohol and alcohol intake in patients suffering from alcohol dependence.
Alcohol and alcoholism  •  2019  |  View Paper
Naltrexone is thought to blunt the reinforcing effects of alcohol , and a few studies have found that the effects of naltrexone are moderated by the Asn40Asp polymorphisms of the OPRM1 gene.
Alcoholism, clinical and experimental research  •  2010  |  View Paper
Naltrexone (NTX), by its pharmacological action in the mesolimbic pathways, should decrease reinforcement from nicotine as well as from alcohol.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco  •  2003  |  View Paper
In the case of NTX pretreatment, the subjects reported significantly (P=.013) less urge to drink alcohol on the self-reporting urge scales, especially at postdrinking 20 min and 60 min than placebo pretreatment.
This results show that the NTX reduced the urge to drink alcohol with the mechanism of partially blocking the opioid positive reward system and partially mimicking the alcohol effect.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  2002  |  View Paper
It is hypothesized that naltrexone may reduce drinking via suppressing craving for alcohol and that this effect may be related in part to naltrexone's ability to activate the hypothalamo–pituitary–adrenocortical axis.
Psychopharmacology  •  2002  |  View Paper
Among patients who completed the 12-week trial, naltrexone reduced the consumption of alcohol.
Addiction  •  2001  |  View Paper
Naltrexone has also been reported to reduce ethanol intake in alcohol-preferring rodents and human alcoholics.
Polish journal of pharmacology  •  2000  |  View Paper
Finally, high doses of naltrexone and alcohol interacted to produce the greatest decreases in liking and best effects.
Neuropsychopharmacology  •  2000  |  View Paper
Overall, the results of this study suggest that NTX affects a number of the components of alcohol drinking sequence, including lowering cravings, decreasing the positive reinforcing effects of alcohol , and increasing headache and nausea, each of which may contribute to reducing alcohol intake.
Alcoholism, clinical and experimental research  •  1999  |  View Paper
Conclusions: These findings show that naltrexone reduces ethanol consumption in healthy volunteers, as it does in alcoholics.
Psychopharmacology  •  1999  |  View Paper
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