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Possible Interaction: Ethanol and Naloxone

supplement:

Ethanol

Research Papers that Mention the Interaction

Also, changes are observed in naloxone pharmacokinetic parameters with the ingestion of alcohol , specifically a decrease in plasma clearance.
Clinical pharmacology and therapeutics  •  1988  |  View Paper
A triple interaction of treatments, antagonist conditions, and drinking experience indicated that naloxone as compared to saline diminished ethanol and placebo analgesia among experienced drinkers but had opposite effects among the same men in the control treatment.
Addictive behaviors  •  1987  |  View Paper
When naloxone was given after ethanol , the first injection reduced slightly but significantly ethanol-induced (1.5 g/kg) nystagmus, while the second injection did not enhance this counteraction any more.
Acta pharmacologica et toxicologica  •  1984  |  View Paper
It has previously been reported that prior administration of naloxone may prevent the decrement in performance produced by alcohol.
Psychopharmacology  •  1981  |  View Paper
CONCLUSIONS The concurrent use of alcohol with heroin resulted in the use of greater than standard doses of naloxone by paramedics in resuscitating overdose patients.
Patients who received greater than the standard dose of naloxone were 2.25 (95% CI, 1.83-2.77) times more likely to have been under the influence of alcohol when consuming the heroin that resulted in overdose.
Resuscitation  •  2005  |  View Paper
Opioid antagonists, like naloxone and naltrexone, decrease ethanol self-administration under a variety of conditions in different species of laboratory animals (e.g., rodents and nonhuman primates).
Alcoholism, clinical and experimental research  •  2001  |  View Paper
However, when ethanol was given together with naloxone , the peak rise induced by breast stimulation was only partially inhibited by ethanol (the mean PRL peak was 46.2% higher than baseline).
In contrast, since naloxone partially reversed the inhibiting effects of ethanol , a partial involvement of opioid peptides in ethanol action is supposed.
The PRL response to breast stimulation was not changed by the treatment with the lower (2 plus 10 mg) or the higher (4 plus 20 mg) dose of naloxone , whereas it was strikingly decreased by ethanol (mean peak was 25% higher than baseline).
Life sciences  •  1994  |  View Paper
However, when ethanol was given together with naloxone , the oxytocin rise induced by breast stimulation was only partially inhibited by ethanol (the mean oxytocin peak was 50% higher than baseline).
In contrast, since naloxone partially reversed the inhibiting effects of ethanol , a partial involvement of opioid peptides in ethanol action is supposed.
Acta endocrinologica  •  1992  |  View Paper
In contrast, since naloxone partially reversed the inhibiting effects of ethanol , a partial involvement of opioid peptides in ethanol action may be supposed.
When ethanol was given together with naloxone , AVP rose by only two-fold in response to hypoglycemia.
Neuroendocrinology  •  1990  |  View Paper
Since naloxone only partially reversed the inhibiting effects of ethanol , only a partial involvement of opioid peptides in ethanol action might be supposed.
Metabolism: clinical and experimental  •  1987  |  View Paper
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